Proteases annotated library
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•Proteases are enzymatic proteins that cleave specific peptide bonds withing other functional proteins •Physiologically the protease enzymatic activity can be modulated by -Mimetics of peptide motifs that bind at a catalytic site -Chelators of specific metal ions that often used by proteases as cofactors •Proteases are well recognized as important therapeutic targets for -Infections, e.g. antibacterial, antiviral, antimalarials -Inflammatory diseases, e.g. fibrosis, NSAID painkillers, joint stiffness -Cardiovascular system, e.g. blood pressure regulation, thrombosis |