CNS CHEMICAL LIBRARIES AND BIOLOGICAL ASSAYS

Design and synthesis for known drugable and novel targets are an important and difficult task. ChemDiv offers the platform approach to designing the diversity of useful synthetic arrays implementing them as discovery tools for a large number of CNS relevant biotargets and pathways. Each chemical library, i.e. discovery tool, is projected from a unique design and synthesis methodology depending on relevance and availability of target, ligand and function information. Proprietary innovative discovery tools have successfully achieved lead and drug candidate milestones for our collaborators. ChemDiv synthesizes more than 200,000 new chemical entities each year and is constantly adding biological assay and animal model capabilities.
Examples of the libraries:

  • Apoptosis
  • Modulators of proliferation and differentiators of stem cells
  • Transporter inhibitors library
  • GABA (A) library
  • mGluR ligands
  • Citokine library
  • HDAC library
  • HSP90 library
  • K+ channels library
  • GSK3b library
  • Methyltransferase inhibitors library
  • MK2 inhibitors library
  • Na+ channels library
  • nAChR libraryPDZ library
  • Phosphatases library
  • Purinergic library
  • Secretase library
  • Serine/Cysteine Proteases inhibitors library
  • GPCR platform se
  • Ion Channels platform set
  • Kinases platform set
  • Signaling and developmental pathway modulators
  • Peptidomimetics
  • Natural-like

Please contact our team at [email protected] to discuss your specific needs and application.

CNS IN VIVO

CNS In Vivo are designed in small animals (rats and mice) and large animal (monkeys) with the objective of providing mechanistic insights into neurodegenerative and psychiatric disease and opportunities for new strategies of therapeutic intervention. ChemDiv adheres to “Good Laboratory Practice” standards to ensure reliability and reproducibility of study results. QC/QA systems encompass SOPs for: study systems, performance, management; handling and analysis of the test items, data and biometrics; confidentiality, identity and security of proprietary compounds and reporting. Unimpaired laboratory animals are required to gain reliable results from behavioral pharmacology. Our quality management therefore focuses in particular on correct animal housing and handling for animal wellbeing, appropriate behavior and generation of valid data

Examples of tests:

The following tests are run routinely and are fully validated. Many additional models can be provided on request:

  • General Behavior
  • Memory Impairment tests
  • Learning & Memory with Aged Animals
  • Anxiety & Fear
  • Psychomotor Behavior & Coordination
  • Depression
  • CNS-mediated Eating Disorders. Obesity.
  • Drug Abuse & Dependence
  • Alcohol and Drug Addiction
  • Anti-depressant Activity Tests:
  • Parkinsonism

General Behavior

  • Open field test
  • Rota-rod test
  • Cross-maze test

Memory Impairment Tests

  • Water maze test (Morris test)
  • Passive avoidance
  • Novel object recognition test

Learning & Memory with Aged Animals

  • Radial Arm Maze
  • Morris Water Maze

Anxiety & Fear

  • Elevated Plus Maze
  • Shock Probe
  • Holeboard
  • Light / Dark Box
  • Passive Shock Avoidance

Psychomotor Behavior & Coordination

  • Excitation & Sedation
  • Exploration
  • Stereotype Behavior
  • Rotarod
  • Catalepsy Test
  • Acoustic startle response test
  • Tilt Plane / Righting Reflex

Depression
Basic Pharmacology & Physiology

CNS-mediated Eating Disorders. Obesity

  • Irwin Test
  • Blood Samples
  • Metabolic Cages

Drug Abuse & Dependence

  • Withdrawal
  • Conditioned Place Preference

Alcohol and Drug Addiction

  • Animal Models for Addiction Development
  • Loss of Control
  • Craving

Anti-depressant Activity Tests

  • Porsolt forced swim test
  • Tail suspension test
  • Elevated platform

Parkinsonism
MPTP-induced motor impairment model

Please contact our team at [email protected] to discuss your specific needs and application.

Take a Look at ChemDiv’s CNS Library