Fragment-Based
Libraries

ChemDiv can assist you in your selection of fragment-oriented libraries for fragment-based drug design approaches. We have thousands of compounds in our collection that fulfill requirements for �lead-likeness� and four intelligent medicinal chemistry filters to further hone in on your specific library ideals.

• Properties to consider
• 1 = HBA = 6
• Solubility:
• water: logSW > -3
• DMSO solubility
• Novelty
• By Beilstein/ SciFinder summary score
• Feasibility
• Scaffold / library
• follow up synthesis or �build out� optimization
• Reagents cost
• Pure available sample
• E.g. 20mg, >95% LCMS
• Functional features to add fragments �friendly� for
• NMR screening compatibility:
• The chemical shifts of protons in design molecules should cover the range from 0 � 12 evenly
• The molecule should posses both alkyl and aromatic protons
• �Marker atoms�, e.g. F
• Access to D, 13C and 15N labeled analogues
• X-ray screening compatibility
• Heavy atoms

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For more information, please email us at libraries@chemdiv.com