ChemDiv offers a wide range of toxicological studies in animal models, specifically in rodents.
Non-GLP toxicology studies can be performed on research grade materials to reduce the cost and increase flexibility of the study design. Such early stage studies can be performed prior to investing substantial time and financial resources in producing a GMP grade material.
ChemDiv strives to provide fast and efficient toxicology studies at affordable cost.
Case Studies:
We offer Maximum Tolerated Dose (MTD) study that is performed to determine the highest dose of a chemical substance that can be administered to a group of test animals so that it does not increase the death rate during a long-term study. The purpose of administering MTD is to determine whether long-term exposure to a chemical substance might lead to any adverse health effects in a population when the level of exposure is not sufficient to cause premature death due to short-term toxic effects. Typically, the end points of the experiment are mortality/survival, morbidity, physiological monitoring and toxicity signs.
ChemDiv offers 7 or 14 days toxicity observation in rodents. Acute toxicity studies describe the adverse effects which result either from a single exposure or from multiple exposures in a short period of time (usually less than 24 hours). To be acknowledged as acute toxicity, the adverse effects should occur within 7-14 days from administration of the substance. The experiment endpoints are the signs of morbidity and mortality, clinical observation, body weight dynamics and at the final stage necropsy: macroscopic evaluation of all animals. Additionally ChemDiv can offer optional histopathology and clinical chemistry testing.
All studies are performed in accordance with a Statement of Work that is developed jointly with the project sponsor to meet the specific study objectives. Custom designed protocols may be developed with a Study Director.
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