Novo Nordisk, Innate Pharma sign agreement for novel cancer immunotherapy

Novo Nordisk, Innate Pharma sign agreement for novel cancer immunotherapy

Innate Pharma today announced it entered into an agreement with Novo Nordisk, granting the France-based company worldwide exclusive rights to develop and commercialize the first drug (IPH5401) in a new class of immuno-oncology therapies.

It is a new investigational anti-C5aR antibody, which completes Innate Pharma’s immuno-oncology pipeline. The company plans to begin developing IPH5401 in 2018. By triggering C5aR, C5a induces accumulation and activation of MDSC (myeloid-derived suppressor cells) and neutrophils in the tumor microenvironment.

These cells are associated with a poor prognosis across numerous tumor types. Indeed, they secrete pro-tumor and pro-angiogenic factors and are associated with resistance to other immuno-oncology treatments. By blocking this pathway, anti-C5aR has the potential to enhance anti-tumor immunity across both solid and hematologic tumors, increasing the efficacy of this therapy approach.

Novo Nordisk conducted two Phase I trials with anti-C5aR in patients with rheumatoid arthritis.The product demonstrated a good safety profile. As part of the agreement, Innate Pharma will make an upfront payment of €40m, plus an additional payment of €370m based on successful completion of precise development, regulatory and sales milestones.

The transaction is expected to close in early July.

4 June 2017

Source: http://www.goinpharma.com/en/

June 5, 2017 / Pharma News