ChemDiv Blog

Beautiful Chemistry

12

May2016

03

Oct2014
In the last few years, the evolution of science has moved at an exponential rate. Presently, medical research has become so profound and widespread that there ... Read More

19

Aug2014
Historically, natural products have been pharma’s treasure trove. According to the Natural Products Library Initiative at the Scripps Research Institute, “from 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being ... Read More

29

Jul2014
Walker et al. (1999) Nature 402, 313-320 Compared to some of the other big targets in drug discovery, PI3 kinase (PI3K) inhibition is clinically advanced. There are dozens of PI3K targeting drugs in clinical ... Read More

23

Jun2014
ChemDiv’s Small Molecule Tools for Protein-Protein Interactions Drug discovery’s greatest successes have been unevenly distributed as far as targets are concerned. It is an often-quoted statistic, for example, that more than one third of all currently marketed drugs target G-protein coupled receptors.... Read More

09

May2014
In the world of cancer drug discovery, the Ras family of G proteins – K-Ras, H-Ras and N-Ras – is a so-far unclaimed prize. Given that a third of all tumors have mutations in a RAS protein, with mutation rates in certain intractable cancer types such as pancreatic ... Read More

Featured Structures

19

Aug2014
ChemDiv’s New Natural Product Chemistry for Anti-Viral, Anti-tumor Development of Podophyllotoxin To learn more about the Chemistry Inspired by Nature read our blog article Podophyllotoxin - Featured Structure of the Month

01

May2014
Featured Scaffold Compound S511-0490 represents a new series of helix-mimetics possessing ... Read More