Publications in 2005

  1. Kravchenko D.V., Kysil V.M., Tkachenko S.E., Maliarchouk S., Okun I.M., Ivachtchenko A.V. Synthesis and caspase-3 inhibitory activity of 8-sulfonyl-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines. Farmaco. 2005; 60(10): 804-9.

  2. Ilyin A.P., Kobak V.V., Dmitrieva I.G., Peregudova Y.N., Kustova V.A., Mishunina Y.S., Tkachenko S.E., Ivachtchenko A.V. Synthesis of annelated azaheterocycles containing a 5-carbamoylpyrazin-3-one fragment by a modification of the four-component Ugi reaction. European Journal of Organic Chemistry. 2005; (21): 4670-4679.

  3. Kravchenko D.V., Kysil V.M., Tkachenko S.E., Maliarchouk S., Okun I.M., Ivachtchenko A.V. Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones. European Journal of Medicinal Chemistry. 2005; 40(12): 1377-1383.

  4. Vvedensky V.Y., Ivanov Y.V., Kysil V., Williams C., Tkachenko S., Kiselyov A., Khvat A.V., Ivachtchenko A.V. Microwave-mediated reactions of 3-aminomethylpyridines with acetylenedicarboxylates. A novel synthetic route to dihydronaphthyridines and naphthyridine-1-ones Tetrahedron Letters. 2005; 46: 3953-3956.

  5. Kravchenko D.V., Kysil V.M., Ilyn A.P., Tkachenko S.E., Maliarchouk S., Okun I.M., Ivachtchenko A.V. 1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2005; 15(7): 1841-1845.

  6. Kravchenko D.V., Kuzovkova Y.A., Kysil V.M., Tkachenko S.E., Maliarchouk S., Okun I.M., Balakin K.V., Ivachtchenko A.V. Synthesis and Structure-Activity Relationship of 4-Substituted 2-(2-Acetyloxyethyl)-8-(morpholine- 4-sulfonyl)pyrrolo[3,4-c]quinoline- 1,3-diones as Potent Caspase-3 Inhibitors Journal of Medicinal Chemistry. 2005; 48(11): 3680-3683.

  7. Ilyin A.P., Kuzovkova J.A., Potapov V.V., Shkirando A.M., Kovrigin D.I., Tkachenko S.E., Ivachtchenko A.V. An efficient synthesis of novel heterocycle-fused derivatives of 1-oxo-1,2,3,4-tetrahydropyrazine using Ugi condensation. Tetrahedron Letters. 2005; 46(5): 881-884.

  8. Balakin KV, Ivanenkov YA, Savchuk NP, Ivashchenko AA, Ekins S. Comprehensive computational assessment of ADME properties using mapping techniques. Current Drug Discovery Technologies. 2005; 2(2): 99-113.

  9. Zhuravel’ IO, Kovalenko SM, Ivachtchenko AV, Balakin KV, Kazmirchuk VV. Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides. Bioorganic & Medicinal Chemistry Letters. 2005; 15(24):5483-7.

  10. Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER, Savchuck NP, Sklar LA, Oprea TI. Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Molecular Pharmacology. 2005; 68(5): 1301-10.

  11. Savchuk N.P., Tkachenko S.E., Balakin K.V. Rational design of GPCR-specific combinatorial libraries based on the concept of privileged substructures. In T Oprea, ed. Cheminformatics in Drug Discovery. Weinheim: Wiley VCH. 2005, pp. 287-313.

  12. Ilyn AP, Trifilenkov AS, Tsirulnikov SA, Kurashvily ID, Ivachtchenko AV. Synthesis of 4-Oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-6-carboxamides using a modification of Ugi condensation. Journal of Combinatorial Chemistry. 2005; 7(6):806-8.

  13. Ilyin AP, Trifilenkov AS, Kurashvili ID, Krasavin M, Ivachtchenko AV. One-step construction of peptidomimetic 5-carbamoyl-4-sulfonyl-2-piperazinones. Journal of Combinatorial Chemistry. 2005; 7(3): 360-3.

  14. Ivachtchenko AV, Kobak VV, Ilyn AP, Khvat AV, Kysil VM, Williams CT, Kuzovkova JA, Kravchenko DV. Parallel liquid-phase synthesis of N-substituted 6-aminosulfonyl-2-oxo-1,2-dihydroquinoline-4-carboxamide and 6-aminosulfonylquinoline-4-carboxamide derivatives. Journal of Combinatorial Chemistry. 2005; 7(2): 227-35.

  15. Ilyn AP, Trifilenkov AS, Kuzovkova JA, Kutepov SA, Nikitin AV, Ivachtchenko AV. New four-component Ugi-type reaction. Synthesis of heterocyclic structures containing a pyrrolo[1,2-a][1,4]diazepine fragment. Journal of Organic Chemistry. 2005; 70(4): 1478-81.

  16. Balakin K.V., Ivanenkov Y.A., Ivachtchenko A.A. Evaluation of pharmacokinetic properties of chemical compounds using special computational algorithms for data analysis // Symposium “Bioinformatics in creating innovative medicines» XII Russian National Congress “Man and medicine.” Moscow, 2005, 18-19 Apr.

  17. Balakin K.V., Ivanenkov Y.A., et al. Effective sharing of computer and real biological screening // Symposium “Bioinformatics in creating innovative medicines» XII Russian National Congress “Man and medicine.” Moscow, 2005, 18-19 Apr.

  18. Balakin K.V., Ivanenkov Y.A., Ivachtchenko A.A. Computer prediction of metabolic properties of low molecular weight organic compounds // Symposium “Bioinformatics in creating innovative medicines» XII Russian National Congress “Man and medicine.” Moscow, 2005, 18-19 Apr.

  19. Balakin K.V., Ivanenkov Y.A., Ivachtchenko A.A. An effective strategy for the optimization of the primary active compounds obtained as a result of high-throughput screening // Symposium “Bioinformatics in creating innovative medicines» XII Russian National Congress “Man and medicine.” Moscow, 2005, 18-19 Apr.

  20. Balakin K.V., Ivanenkov Y.A., et al. Modeling pharmacokinetic and metabolic properties of drug compounds using special methods of computer analysis of the data // International Congress “Biotechnology: State and Prospects” Moscow, 2005, 14-18 March.

  21. Ivanenkov Y.A., Balakin K.V., et al. Modern methods of computer screening of chemical compounds based on special algorithms, data analysis // International Congress “Biotechnology: State and Prospects” Moscow, 2005, 14-18 March.

  22. Balakin K.V., Ivanenkov Y.A., et al. Modeling of the formation of non-covalent complexes efficiency “drug compound – protein” by special methods of computer analysis of the data // International Congress “Biotechnology: State and Prospects” Moscow, 2005, 14-18 March.

  23. Balakin K.V., Ivanenkov Y.A., et al. Modeling of permeation of low molecular weight organic compounds across biological membranes using special methods of computer analysis // International Congress “Biotechnology: State and Prospects” Moscow, 2005, 14-18 March.

  24. Balakin K.V., Ivanenkov Y.A., et al. Computer and real biological screening of low molecular weight organic compounds, synergism new technologies to intensify the search for new drug substances // International Congress “Biotechnology: State and Prospects” Moscow, 2005, 14-18 March.

  25. Balakin K.V., Ivanenkov Y.A., et al. Optimization of pharmacologically important properties of chemical compounds with the help of special computer expert systems // International Congress “Biotechnology: State and Prospects” Moscow, 2005, 14-18 March.

  26. Ivanenkov Y.A., Kravchenko D.V., et al. Design and synthesis of new derivatives of quinoline. Evaluation of inhibitory potency relative to caspase-3 // International Conference on Heterocyclic Chemistry, dedicated to the 90th anniversary of Professor A.N. Costa, Moscow. Moscow State University. M.V. Lomonosov.2005, 17-21 Oct.

  27. Balakin K.V., Ivanenkov Y.A. The synthesis of libraries of organic compounds with predicted properties // International Conference on Heterocyclic Chemistry, dedicated to the 90th anniversary of Professor A.N. Costa, Moscow. Moscow State University. M.V. Lomonosov.2005, 17-21 Oct.

  28. Ivachtchenko A.V. Substituted sulfonyl-7-benzo [b] [1,4] diazepines, methods of their preparation, and pharmaceutical focused libraries activity. Pat. RF 2261246 (2005).

  29. Zhuravel I. A.; Ivachtchenko A.V.; Kovalenko S. N.; Tkachenko S. E.; Chernykh V. P.; Okun I.M. Substituted 2H-pyrano [2,3-c] pyridines and focussed combinatorial library. Pat. RF 2261251 (2005).

  30. Dorogov M. V.; Solovyov M. Y.; Kravchenko D. V.; Tkachenko S. E.; Ivachtchenko A.V. Heterocyclic compounds including 2-aminopyridine-3-sulfonic moiety, methods of making, and focused libraries pharmaceutical composition. Pat. RF 2263667 (2005).

  31. Ivachtchenko A. V.; Ilyin A.P.; Kobak V. V.; Kravchenko D. V.; Khvat A. V.; Tkachenko S. E; Okun I. M. A combinatorial preparation of N-containing heterocycles, useful as caspase-3 inhibitors. Int. Pat. Appl. WO 2005018531 (2005).

  32. Ivachtchenko A. V.; Vvedensky V. Yu.; Ivanov, Yu. V.; Kysil V. M.; Khvat A. V.; Tkachenko S. Y.; Okun I. M. A preparation of focused library of 1,2-dihydro[2,7]naphthyridine derivatives, useful as mediators of nicotinic receptors. Int. Pat. Appl. WO 2005026166 (2005).

  33. Ivachtchenko A. V.; Vvedensky V. Y.; Ilyin A. P.; Kysel, V. M.; Khvat A. V.; Kuzovkova, Y. A.; Kutepov, S. A.; Dmitrieva I. G.; Zolotarev, D. A.; Tkachenko S. Y.; Okun I. M.; Kravchenko D. V.; Kobak V. V.; Trifilenkov A. S.; Mishunina Y. S.; Loseva, M. V.; Rizhova, E. A.; Parchinsky, V. Z.; Tsirulnikov, S. A.; Kyselev, A. S. Annelated carbamoylase-heterocycles, focused library, pharmaceutical compositions and methods for the production and use thereof. Int. Pat. Appl. WO 2005105805 (2005).