Because of the central role in the cellular biology of prostate cancer, androgen receptor (AR) is an important therapeutic target for fighting this tumor.
The library has been designed around 21 core structures (in fact, this is not limit and more cores can be identified for further library expansion).
Each of these cores is able to provide 1-3 scaffolds, so entire library has been populated around 51 scaffolds.
23 scaffolds have been finally selected and prioritized for the library synthesis:
Priority # 1 – 14 scaffolds,
Priority # 2 – 4 scaffolds,
Priority # 3 – 5 scaffolds;
4.3K-members Library around 17 scaffolds has been synthesized.
Medicinal and Computational Chemistry Dept., ChemDiv, Inc.
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