Historically, natural products have been pharma’s treasure trove. According to the Natural Products Library Initiative at the Scripps Research Institute, “from 1940s to date, 131 (74.8%) out of 175 small molecule …
In the world of cancer drug discovery, the Ras family of G proteins – K-Ras, H-Ras and N-Ras – is a so-far unclaimed prize. Given that a third of all tumors have mutations in a RAS protein, with …