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Covalent Fragments Smart Library

799 compounds

ChemDiv’s Covalent Fragments Smart Library contains 799 compounds.

Drug design of small molecules is based on their ability to interact with their biological targets under equilibrium binding states. These binding states occur in a fast and reversible process, which affects the duration of the therapeutic response. Thus, prolongation of therapeutic response can be extended by increasing the duration of interaction between a drug and its target. This type of prolonged interaction can be achieved by covalent inhibitors. Covalent inhibitors bind to their target in two steps, starting with equilibrium bond formation, and ending with covalent bond formation. The final state is considered to be irreversible, resulting in a drug–protein complex that is different from that formed with a normal equilibrium bond. The covalent bond can be either reversible or irreversible, depending on the chosen warhead. A number of different warheads have been exploited to target specific amino acid residues, including among others cysteine, serine, threonine, tyrosine and lysine. [1]

ChemDiv offers the smart library of covalent inhibitors. The main criteria for members selections are:
1) Should be rationally designed as members of Smart LCI
2) Core structures (including warhead) should meet the criteria applied for the general fragment library.

[1] F. Sutanto, M. Konstantinidou, and A. Dömling, “Covalent inhibitors: A rational approach to drug discovery,” RSC Med. Chem., vol. 11, no. 8, pp. 876–884, 2020, doi: 10.1039/d0md00154f

Crystallographic and 19F NMR fragment-libraries

Medicinal and Computational Chemistry Dept., ChemDiv, Inc.
12760 High Bluff Dr, San Diego, CA, 92130
Phone: + 1 916 234 0888
Fax: +1 858 794 4931
Email: ChemDiv@chemdiv.com

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You can buy this library or customize your own library from our discovery collection of 1 600 000 compounds and 60 000 building blocks.

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