Design and synthesis for known drugable and novel targets are an important and difficult task. ChemDiv offers the platform approach to designing the diversity of useful synthetic arrays implementing them as discovery tools for a large number of CNS relevant biotargets and pathways. Each compound library, i.e. discovery tool, is projected from a unique design and synthesis methodology depending on relevance and availability of target, ligand and function information. Proprietary innovative compound libraries have successfully achieved lead and drug candidate milestones for our collaborators. ChemDiv synthesizes more than 200,000 new screening compounds each year and is constantly adding biological assay and animal model capabilities.
Examples of the compound libraries:
Apoptosis
Modulators of proliferation and differentiators of stem cells
Transporter inhibitors library
GABA (A) library
mGluR ligands
Citokine library
HDAC library
HSP90 library
K+ channels library
GSK3b library
Methyltransferase inhibitors library
MK2 inhibitors library
Na+ channels library
nAChR libraryPDZ library
Phosphatases library
Purinergic library
Secretase library
Serine/Cysteine Proteases inhibitors library
GPCR platform se
Ion Channels platform set
Kinases platform set
Signaling and developmental pathway modulators
Peptidomimetics
Natural-like
Please contact our team at chemdiv@chemdiv.com to discuss your specific needs and application.
CNS IN VIVO
CNS In Vivo are designed in small animals (rats and mice) and large animal (monkeys) with the objective of providing mechanistic insights into neurodegenerative and psychiatric disease and opportunities for new strategies of therapeutic intervention. ChemDiv adheres to “Good Laboratory Practice” standards to ensure reliability and reproducibility of study results. QC/QA systems encompass SOPs for: study systems, performance, management; handling and analysis of the test items, data and biometrics; confidentiality, identity and security of proprietary compounds and reporting. Unimpaired laboratory animals are required to gain reliable results from behavioral pharmacology. Our quality management therefore focuses in particular on correct animal housing and handling for animal wellbeing, appropriate behavior and generation of valid data
Examples of tests:
The following tests are run routinely and are fully validated. Many additional models can be provided on request:
General Behavior
Memory Impairment tests
Learning & Memory with Aged Animals
Anxiety & Fear
Psychomotor Behavior & Coordination
Depression
CNS-mediated Eating Disorders. Obesity.
Drug Abuse & Dependence
Alcohol and Drug Addiction
Anti-depressant Activity Tests:
Parkinsonism
General Behavior
Open field test
Rota-rod test
Cross-maze test
Memory Impairment Tests
Water maze test (Morris test)
Passive avoidance
Novel object recognition test
Learning & Memory with Aged Animals
Radial Arm Maze
Morris Water Maze
Anxiety & Fear
Elevated Plus Maze
Shock Probe
Holeboard
Light / Dark Box
Passive Shock Avoidance
Psychomotor Behavior & Coordination
Excitation & Sedation
Exploration
Stereotype Behavior
Rotarod
Catalepsy Test
Acoustic startle response test
Tilt Plane / Righting Reflex
Depression
Basic Pharmacology & Physiology
CNS-mediated Eating Disorders. Obesity
Irwin Test
Blood Samples
Metabolic Cages
Drug Abuse & Dependence
Withdrawal
Conditioned Place Preference
Alcohol and Drug Addiction
Animal Models for Addiction Development
Loss of Control
Craving
Anti-depressant Activity Tests
Porsolt forced swim test
Tail suspension test
Elevated platform
Parkinsonism
MPTP-induced motor impairment model
Please contact our team at chemdiv@chemdiv.com to discuss your specific needs and application.
