Human Proteases Annotated Library

Proteases are involved in digesting long protein chains into shorter fragments by splitting the peptide bonds that link amino acid residues. Some detach the terminal amino acids from the protein chain (exopeptidases, such as aminopeptidases, carboxypeptidase A); others attack internal peptide bonds of a protein (endopeptidases, such as trypsin, chymotrypsin, pepsin, papain, elastase).

Human Proteases Annotated Library

3,000 Compounds

• Proteases are enzymatic proteins that cleave specific peptide bonds withing other functional proteins
• Physiologically the protease enzymatic activity can be modulated by
– Mimetics of peptide motifs that bind at a catalytic site
– Chelators of specific metal ions that often used by proteases as cofactors
• Proteases are well recognized as important therapeutic targets for
– Infections, e.g. antibacterial, antiviral, antimalarials
– Inflammatory diseases, e.g. fibrosis, NSAID painkillers, joint stiffness
– Cardiovascular system, e.g. blood pressure regulation, thrombosis
A unique collection of small molecule compounds with annotated activities for Proteases protein targets
❑ Annotated activities : 60 protease targets
❑ Express Delivery : 320 compounds
❑ Complete Version : 2976 compounds

Medicinal and Computational Chemistry Dept., ChemDiv, Inc.
12760 High Bluff Dr, San Diego, CA, 92130
Phone: + 1 916 234 0888
Fax: +1 858 794 4931
Email: ChemDiv@chemdiv.com

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