ChemDiv provides integrated discovery chemistry programs by exploring two major approaches, i) de novo search for principally novel chemical entities from our ever expanding‑small molecule library of more than 1.6M compounds and ii) fast follow forward repurposing and optimization of known and clinically tested entities through an innovative medicinal chemistry approaches. Through many years of successful collaborations, we have accumulated a strong knowledge and assembled technologies that are being utilized for discovery chemistry against majority of target classes and our scientists have proven experience of progressing projects from screening to the clinic.
As a preeminent discovery chemistry provider, ChemDiv has built an infrastructure with a complete array of systems to meet our client’s modern challenges. No matter where you are in your development pipeline, you may find ChemDiv’s products and services to be of considerable value. Our streamlined process from Hit Seeking through Lead Optimization and into POC and clinical trials will ensure your project runs efficiently and in a timely manner.
Our Biology on Demand Program offers our partners a unique time and cost efficient platform solutions for discovery chemistry: Assay development, High Throughput Screening and ADME/Tox assessment. We are proud to offer our partners a great number of various assays developed and implemented by expert professionals.
By integrating all project activities into one project management team, ChemDiv offers an excellent resource for efficient use of capital.
Please contact our team at chemdiv@chemdiv.com to discuss your specific needs and application.
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ChemDiv’s team of trained and highly experienced scientists is proud to offer unparalleled expertise in developing and accommodating assays for HTS format and designing orthogonal assays for early identification and removal of false positive hits from further costly follow up processes. Not being limited to a third party libraries for screening and by offering our proprietary focused discovery sub-libraries assembled from the ChemDiv’s ever-growing collection of 1.5 million small molecules, being synthesized based on unique ideas of novel templates, provides tremendous benefits for high throughput hit hunting. Unique design of these sublibraries provides a very robust way for early mini-SAR analysis for identification and confirmation of hit series, which then become seed templates for hit expansion, hit-to-lead exploration, and medicinal chemistry lead optimization.
A robust screening platform encompassing automated liquid handling and multimode signal detection equipment have been assembled at ChemDiv to be able to provide access to screening assays for multiplicity of targets, such as receptors, enzymes, signaling pathways etc., which play major role in different therapeutics areas (oncology, immunology, CNS, metabolic diseases).
We have assembled a robust screening infrastructure to be able to work with targets of major therapeutics areas. Our technical park of Discovery Division includes:
Equipment
- Liquid Handling
- Biomek 2000,
- Biomek NX,
- Biomek FX work station
- 96/384-well plate readers;
- FLIPR-Tetra (Molecular Devices)
- Microbeta PLUS 1450 (PerkinElmer),
- scintillation counters;
- Victor2V and Victor 3 multimode;
- SpectraMax Plus 96/384;
- Mach III (Tomtec) 96-well cell harvester;
- Beckman and GUAVA 96/384 well format Flow Cytometers.
Readout capabilities
- Luminescence: Reporter genes; ELISAs;
- Fluorescence: FLINT, FRET, TR-FRET, FP, GFP; ELISAs
- Radio-Isotope: Receptor assays (ligand-binding/competition), SPA, metabolic enzymes
Absorbance: OD, ABS spectra
Ready to deploy assays
- In vitro assays:
- FLIPR (cytoplasmic and mitochondrial calcium),
- LANCE (cytoplasmic cAMP/cGMP),
- ELISA,
- Western,
- Kinase activity, Enzymatic activity
- Cell Assays:
- cell growth,
- cell cycle analysis,
- apoptosis/necrosis,
- in vitro chemoinvasion,
- high content high throughput microscopy
- Molecular and Cell Biology:
- Custom Expression / Reporter Constructs;
- Transient/stable transfection.
- Cell lines and primary cultures;
Please contact our team at chemdiv@chemdiv.com to discuss your specific needs and application.
- Liquid Handling
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ChemDiv has assembled a robust high throughput screening platform encompassing automated liquid handling and multimode signal detection equipment for assays to be ran in up to 1536-well plate formats. Multimode reading capability provides access to screening assays with multiplicity of targets, such as receptors, enzymes, signaling pathways etc. that play a major role in different therapeutics areas (oncology, immunology, CNS, metabolic diseases).
ChemDiv offers logistics and compound handling support to High Throughput Screening (HTS) performed at our facilities, which substantially reduces time and eliminates costs associated with compounds shipments and plate preparations. Decades of stellar experience of being a worldwide manufacturer and supplier of chemical libraries to drug discovery institutions, uniquely positions ChemDiv, with its logistics infrastructure, to be able to backtrack every hit to its specific QC data for the original compound on the plate. Our proprietary focused discovery sub-libraries assembled from the ChemDiv’s ever-growing collection of 1.5 million small molecules, being synthesized based on novel templates ideas, provide tremendous benefits for high throughput hit hunting in terms of both potential hit novelty and follow up synthetic hit expansion. Unique design of these sublibraries provides a very robust way for early chemoinformatics-based identification and confirmation of hit compounds with immediate mini-SAR cluster analyses offering seed scaffolds, or starting points, for hit expansion, hit-to-lead exploration, and medicinal chemistry lead optimization.
We have assembled a robust screening infrastructure to be able to work with targets of major therapeutics areas. Our technical park of Discovery Division includes:
Equipment
- Liquid Handling
- Biomek 2000,
- Biomek NX,
- Biomek FX work station
- 96/384-well plate readers;
- FLIPR-Tetra (Molecular Devices)
- Microbeta PLUS 1450 (PerkinElmer),
- scintillation counters;
- Victor2V and Victor 3 multimode;
- SpectraMax Plus 96/384;
- Mach III (Tomtec) 96-well cell harvester;
- Beckman and GUAVA 96/384 well format Flow Cytometers.
Readout capabilities
- Luminescence: Reporter genes; ELISAs;
- Fluorescence: FLINT, FRET, TR-FRET, FP, GFP; ELISAs
- Radio-Isotope: Receptor assays (ligand-binding/competition), SPA, metabolic enzymes
Absorbance: OD, ABS spectra
Ready to deploy assays
- In vitro assays:
- FLIPR (cytoplasmic and mitochondrial calcium),
- LANCE (cytoplasmic cAMP/cGMP),
- ELISA,
- Western,
- Kinase activity, Enzymatic activity
- Cell Assays:
- cell growth,
- cell cycle analysis,
- apoptosis/necrosis,
- in vitro chemoinvasion,
- high content high throughput microscopy
- Molecular and Cell Biology:
- Custom Expression / Reporter Constructs;
- Transient/stable transfection.
- Cell lines and primary cultures;
Custom Assay Development (per Clients’ specification)
Please contact our team at chemdiv@chemdiv.com to discuss your specific needs and application.
- Liquid Handling
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