Ion Channels Focused Library

26,000 Compounds

A unique collection of small molecule compounds selected for Ion Channels protein targets
 Therapeutically relevant 57 ion channels (119 protein sub-families/units targets in total)
 Recent literature data from 509 research papers and patents published since 2014
 The most recent (2019 and 2020) X-Ray and Cryo-EM structures from PDB
 Comprehensive Ion Channels Platform Library : 26,000 compounds

Ion channels are pore-forming proteins that allow the flow of ions across membranes
Physiologically the Ion Channels are regulated by
– voltage, e.g. most Na, K, Ca and some Cl channels are “voltage-gated ion channels”
– intracellular and/or extracellular mediators, e.g. some K and Cl channels, TRP channels, GABA(A) and P2X receptors are “ligand-gated ion channels”
Ion channels are well recognized as important therapeutic targets for diseases of
– the central nervous system (CNS), e.g. sleep disorders, anxiety, epilepsy, pain
– the peripheral nervous system, e.g. anticonvulsant, analgesic, anti-inflammatory
– the cardiovascular system, e.g. ischemia, hypoxic conditions, stroke

Ion Channels Focused Library Selection_examples

Medicinal and Computational Chemistry Dept., ChemDiv, Inc.
12760 High Bluff Dr, San Diego, CA, 92130
Phone: + 1 916 234 0888
Fax: +1 858 794 4931
Email: ChemDiv@chemdiv.com

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