A drug that boosts activity in the brain’s “garbage disposal” system may decrease levels of toxic proteins linked with Alzheimer’s and other neurodegenerative diseases, scientists have found for the first time.
“We have shown for the first time that it’s possible to use a drug to activate this disposal system in neurons and effectively slow down disease,” said study leader Karen E Duff, professor at Columbia University Medical Centre (CUMC) and at the New York State Psychiatric Institute.
“This has the potential to open up new avenues of treatment for Alzheimer’s and many other neurodegenerative diseases,” Duff said.
The drug used was rolipram, which causes nausea and thus is not a good drug for use in humans, but similar drugs do not incur nausea as a side effect and could go into clinical trials very quickly.
To remain healthy, brain cells must continually clear out old, worn, or damaged proteins, a task performed by a small molecular cylinder called the proteasome.
The proteasome acts as a kind of garbage disposal, grinding up the old proteins so they can be recycled into new ones.
In neurodegenerative diseases, proteins tagged for destruction accumulate in the brain’s neurons, suggesting that the cell’s proteasomes are impaired.
Using a mouse model of neurodegeneration, the researchers first discovered that tau – a toxic protein that accumulates in Alzheimer’s and other brain degenerative diseases – sticks to the proteasome and slows down the protein disposal process.
Administering rolipram activated the proteasome and restored protein disposal to normal levels. The drug also improved the memory of diseased mice to levels seen in healthy mice.
Rolipram has been tested before in mice and was shown to improve memory, but the mechanism for how this occurred was unclear.
The new research shows that by inhibiting of the PDE-4 enzyme, rolipram produces a physical change in the proteasome that increases its activity.
“We still don’t know exactly where the activation is happening, but what’s new is that we can modify the proteasome to increase its activity. There could be many other ways to do this,” said the study first author Natura Myeku, an associate research scientist at CUMC.
Drugs that target proteasomes in this way should work for any disease caused by the accumulation of abnormal proteins, including Alzheimer’s, Huntington’s, Parkinson’s and frontotemperoral dementia.
“Treatments that speed up these cell disposal mechanisms should, in theory, only degrade abnormal proteins. We don’t need to know what the toxic form of the protein is,” Duff said.
“In Alzheimer’s disease, there are at least four different types – amyloid, tau, alpha-synuclein, and TDP43. A well-functioning proteasome can clear out everything at once,” he said.
The study was published in the journal Nature Medicine.
December 22, 2015