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ACTIVITY DATA AGAINST 5 BACTERIA AND
2 FUNGI IN OUR BRAND NEW LIBRARY

ACTIVITY DATA AGAINST 5 BACTERIA AND
2 FUNGI IN OUR BRAND NEW LIBRARY

ChemDiv presents a brand new library – Opportunistic Pathogens of Immunocompromised Hosts
Annotated Library (OPICH library), which consists of over 2,500 compounds.

BREAKING WORLD PHARMA NEWS
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ChemDiv presents a brand new library – Opportunistic Pathogens of Immunocompromised Hosts Annotated Library (OPICH library), which consists of over 2,500 compounds.
The library also includes activity data against 5 bacteria and 2 fungi. Each compound is annotated with toxicity data on human embryonic kidney cells as well as human red blood cells.

Opportunistic Infections (OIs) still remain a major cause of morbidity and death with either malignant or non-malignant diseases. Opportunistic Infections (OIs) are defined as infections occurring due to bacteria, fungi, viruses, or parasites that normally do not cause a disease, but become pathogenic when the body’s defense system is impaired. OIs can also be represented by unusually severe infections caused by common pathogens.

The available data package includes:
  • Names of pathogens: Straphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Acinetobacter baumanii, Pseudomonas aeruginosa, Candida albicans, Cryptococcus neoformans var. grubii.
  • Table with Percentile(50%) values of MIC, CC50 (cytotoxicity) and HC10 (haemolytic activity) for each organism.
  • Table with individual MIC, CC50 (cytotoxicity) and HC10 (haemolytic activity) values for each organism, as well as Dmax values.
  • Individual data points for import in in-house databases. Haemolysis also reports the HC50 values, which are used to calculate the HC10 values.
This library is available for immediate shipping and could be conveniently formatted in any type of 96- or 384-well plates.
DOWNLOAD COMPLETE DATABASE
OF 1.6 M STOCK COLLECTION COMPOUNDS
AND 60,000 BUILDING BLOCKS
SEARCH AND ORDER ONLINE:
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FOCUSED, TARGETED, ANNOTATED, DIVERSE LIBRARIES
FROM CHEMDIV
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OUR MOST POPULAR SCREENING LIBRARIES
In addition to our newest compound collections, please take a look at our most popular libraries:
300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (300,000 compounds) Structures
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PLpro Library (6,442 compounds) Structures
ACE2 Library (3,117 Compounds) Structures
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Ion Channels Focused Library 26,000 compounds) Structures
Histone Deacetylases (HDAC) Targeted Library (9,500 compounds) Structures
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Lipid Metabolism Library (9,000 compounds) Structures
Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (33,000 compounds) Structures
Purine Based Nucleoside Library (1,300 compounds) Structures
STING Agonist Library (6,000 compounds) Structures
Nucleoside Mimetics Library (2,600 compounds) Structures
Receptor protein tyrosine phosphatases (3,900 compounds) Structures
Selective Target Activity Profiling library (18,000 compounds) Structures
Regenerative Medicine Focused Library (23,000 compounds) Structures
Neurotransmitter Transporter Inhibitors library (12,000 compounds) Structures
MCE-18 Trends in Medicinal Chemistry (50,000 compounds) Structures
Epitranscriptome Focused Small Molecule Library (21,000 compounds) Structures
Cardiovascular Library (23,000 Compounds) Structures
RNA Isosteric Trinucleotide Mimetics Library (29,000 compounds) Structures
Protein Kinases Inhibitors Library (38,000 compounds) Structures
Antibacterial Compounds Library (15,000 compounds) Structures
Therapeutical Diversity Annotated Library (8,500 compounds) Structures
Covalent Inhibitors Library (12,000 compounds) Structures
We will be happy to hear your requests, comments or questions at chemdiv@chemdiv.com
DRUG DISCOVERY SOLUTIONS
> High Throughput Screening Services
(HTS assay set-up, validation and screening)
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> Synthetic and Medicinal Chemistry Services
(Hit-to-Lead Optimization, Lead-optimization or Custom library synthesis)
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(Scaffold Hopping, AI-assisted target deconvolution, QSAR Modeling & other services)
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> Compound Profiling
(ADME, PK, TOX & other assays)
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We will be happy to hear your requests, comments or questions at lt@chemdiv.com or sb@chemdiv.com or chemdiv@chemdiv.com
November 20, 2020 / Blog
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