CNS, Onco, Metabolic

CNS chemical libraries design and synthesis for known drugable and novel targets are an important and difficult task. ChemDiv offers the platform approach to designing the diversity of useful synthetic arrays implementing them as discovery tools for a large number of CNS relevant biotargets and pathways. Each chemical library, i.e. discovery tool, is projected from a unique design and synthesis methodology depending on relevance and availability of target, ligand and function information. Proprietary innovative discovery tools have successfully achieved lead and drug candidate milestones for our collaborators.

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PDF CNS chemical libraries

CV- and Metabolic diseases-related chemical libraries are designed to simplify the very difficult task of identification and development of successful small molecule drugs. Complexity of identified targets, need for more targets, high level toxicity and ADME requirements associated with this area of research are what catalyze ChemDiv’s involvement in CV and Metabolic diseases. Several comprehensive approaches have been employed for the design, synthesis and selection of proposed libraries: development of peptidomimetics, analysis of a specific disease’s “targetscape” and selection of appropriate prototypes for virtual screening exercise, neural networks scaffolds sorting, and others. With new chemical libraries, ChemDiv offers excellent chemical starting points for discovery applications and follow-up development.

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Oncology-related chemical libraries constitute one of the most important directions of development at ChemDiv. Carefully designed focused or target-biased libraries are comprehensive and cost effective approaches toward development of existing programs and design of new programs in this area. Multiple design tools and approaches have been implemented in order to create the library sets. Starting with a broad analysis of the existing oncology “targetscape” and following with various chemoinformatic tools for selection of specific libraries (ligand hoping, flexible docking, pharmacophore search, etc.), ChemDiv is offering more than 30 different chemical libraries with a variety of new scaffolds to choose from.

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PDF Oncology chemical libraries