ChemDiv is your partner of choice for preclinical profiling backed up by our expertise in screening, biological evaluation, and pre- clinical optimization of small molecules against numerous internally developed and partner targets. ChemDiv can shorten your route from lead generation to clinical research by providing a full scope of preclinical testing to ensure the safety of your drug candidate and provide the data required for IND filing. 1-24 week toxicity studies are performed in small and large animal species with variety of dosing regimens.
CORE CAPABILITY
ChemDiv has established facilities to perform HTS screening and follow-up biological testing of hits and leads up to preclinical ADMET animal studies. The suite of services includes in silico rational drug design and assessment of chemistry's IP-position, available collection or the high throughput synthesis of de novo libraries, screening against the partner's choice of therapeutic targets, follow-up kinetic and mechanistic evaluation of the hits discovered, medicinal chemistry lead optimization, and testing in early animal PK/Tox studies.
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APPLICATION: DRUG DISCOVERY
ChemDiv's preclinical development services in combination with its extensive medicinal and synthetic chemistry expertise facilitates drug discovery projects of our partners through:
- The Focused Diversity™ approach to design of screening libraries
- Development of assay systems based on in-house or third-party targets
- Development and optimization of primary and secondary screens
- Assay adaptation and optimization for high-throughput screening formats (96, 384)
- Medicinal chemistry and optimization of hits and leads
- In vitro and in vivo ADMET, and animal models
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IN VITRO DISCOVERY SERVICES
Features of the Targeted Collection include:
- Enzymatic assays Kinases, Phosphatases, Proteases
- Kinases, Phosphatases, Proteases
- Cell based functional and binding assays GPCRs, Ion channels, Fluorescent and Radioisotope detection
- GPCRs, Ion channels, Fluorescent and Radioisotope detection
- Apoptosis / Necrosis
- Cell proliferation / differentiation
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EARLY IN VITRO ADMET PROFILING
- Phys.Chem. properties
- Solubility in aqueous solutions
- ÐÀÌPA
- Biochemical properties
- Human serum albumin binding
- CYP450 inhibition (microsomes, recombinant proteins)
- hERG inhibition
- Manual patch-clamp
- HTS patch-clamp
- Cell based tox
- Cytotoxic and Cytostatic effects
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IN VIVO SERVICES
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ÑUSTOM ASSAY DEVELOPMENT
- Clients' assays
- Low throughput/labor intensive assays
(e.g., patch-clamp, histochemistry, etc.)
The ChemDiv pre-clinical development offering includes access to our synthetic chemistry and medicinal chemistry expertise and provides a one-stop solution for drug discovery outsourcing.
Please contact ChemDiv to discuss your synthetic chemistry needs!
Register here for the secure Customer Area to obtain access to advanced ChemDiv services, databases and a personalized space.
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