ChemDiv is the partner of choice for screening libraries due to its experience in building a library of close to 1 million drug-like compounds that meet the criteria of the pharmaceutical industry's hit-to-lead discovery process.
FEATURES OF THE SCREENING LIBRARIES INCLUDE:
- Discovery (90% of total library) and Targeted Collection
(10% of total library)
- More than 10,000 chemical templates representing over 1 million compounds
- 200,000 new compounds based on 1,500 new templates
developed annually
- Pre-filtration using Rule-of-Five analysis and MedChem filters
- Comprehensive QC of all compounds
- QC by NMR, HPLC/MS or LC MS and other options
- Compound replenishing and back-up guarantee
FOCUSED DIVERSITY™ APPROACH
The Focused Diversity™ approach and computational algorithms have been developed to assist in the analysis of chemical space, and characterization of target/ligand interactions:
- Fragment and property based diversity, completeness and lead likeness
- Strategic surveillance and novelty assessment
- Feasibility, parallel synthesis and validation
- Unique intermediate and protocol development
- QSAR and non-linear modelling
- High throughput QC
- Data mining and IT platform integration
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TARGETED LIBRARIES
Features of the Targeted Collection include:
- Size of library provided dependent on HTS capability
- Quarterly updated with proprietary compounds
- Target biased selections
- kinase, GPCR, phosphatase, ion channel, protease, nuclear receptor
- Antibacterial, Antiviral Selections
- Novel target based selections
- Hsp90, CB2, NaPi2b cotrasporter
- Recognition motifs and peptidomimetics
- Arg, Pro, Glu, Asp; beta-, gamma-turns; dipeptide- and tripeptide mimics
- including RGD, AVPI and PDZ motifs, beta sheet, SH2 mimics
- Lead-like selection (Rule-of-Three) subsets biased for X-ray and NMR studies
- Natural products and respective synthetic libraries
- Focused Diversity Library annotated against orthogonal classes of targets
- Pathway and Cellular Process targeting compounds including annotated sets
- Antimitotics (vasculature-targeting agents (VTA), non-toxic MT modulators, kinesin, MAP binders)
- Hh-, Wnt- , HIF1-, pathway biased libraries
Please contact your regional account representative for additional information
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