Synthetic chemistry

ChemDiv is the partner of choice for synthetic chemistry research due to its extensive core and custom synthesis capability as well as a unique collection of synthetic building blocks and proprietary intermediates.

ChemDiv’s synthetic chemistry expertise includes:

Heterocyclic chemistry
- Variety of aromatic and unsaturated N, O, S heterocyles
- Natural products and natural-like systems with several chiral senters
- Heterocylic systems with improved solubility and stability
Modern organic synthesis techniques
- Organometalic chemistry: Suzuki, Sоnоgаshira, Heck, Grabbs, Buckwald, large scale Li, Mg, Zn reactios, etc.
- Microwave assisted synthesis, both liquid and solid phase
- Highthrouput analysis (LCMS, HPLC, multi-nuclear NMR)
- Highthrouput purification (HPLC, mass-directed HPLC, SPE, UV FPLC)
Solid support chemistry
- 10-10,000 compounds parallel synthesis
- Solid-phase catalysts, scavenger resins
- Gram scale solid-phase synthesis
Optically active materials
- Assymetric synthesis
- Enantiomers and diastereomers separation and indentification
- Analysis and purification (chiral HPLC, optical rotation, LSR)
- Absolute and relative stereochemistry assignment (X-ray)
Special conditions
- High pressure reactions (up to 200 bar)
- Large scale hydrogenation
- Large scale reactions (up to 30 L)
- Large scale purification

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CHEMDIV SYSTEMS ON DEMAND

ChemDiv has designed and validated the largest portfolio of chemical library systems based on > 10000 heterocylic scaffolds, diverse reactions and building blocks. Libraries could be customized according to partner specifications within broad chemistry space with minimum redevelopment effort.

Library system design strategies:

Proven synthetic feasibility
Privileged structure search, literature annotation
Knowledge mining for IP score optimization (SciFinder, Beilstein, Integrity)
Rational design, bioisosteric morphing
Natural-like peptidomimetic and lead-like motifs and structures
Optimization of diversity and phys-chem parameters
ADMETox parameters optimization
Annotation with in vitro and in vivo experimental biology data

CUSTOM SYNTHESIS

ChemDiv offers partners a variety of options, including:

Proprietary client’s target or scaffold based library design and parallel synthesis (20 – 2000 analogs/scaffold)
Exclusive or semi-exclusive modification of ChemDiv’s proprietary library systems
Broad or specific chemical and biological annotation
Proprietary collection of>4000 highly functionalized building blocks
Development and transfer of protocols and key intermediates
Material(s) delivery on a 1 mg - 10 kg scale, > 90-99% purity
High-throughput 1H NMR, MS/HPLC and purification