Library of Modulators of Protein-Protein Interactions (PPI)

B

etween 40,000 and 200,000 protein-protein interactions have been predicted to exist within the human interactome

Protein-protein interactions (PPIs) play a key role in nearly every biological function and are a promising new class of biological targets for therapeutic intervention

Design Principles

  • Diversity
  • 3D-Shape
  • Escape from flatland
  • Drug-likeness
  • Natural product likeness
  • Targeted Diversity

Examples of PPI Targeted Chemistry & Libraries

Chemokine pGPCRs: CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CCR8,CXCR1, CXCR2, CXCR3, CXCR4;
Other pGPCRs: Galanin Gal1, Gal3; Bradykinin B1, B2; Neurotensin NT1, NT2;Orexin OX1, OX2; Opioid-like ORL-1; Tachykinin NK1, NK2, NK3; Bombesin BB1,BB2, BB3; Urotensin UTR2; Protease-activated receptor 1; Glucagon GR;Glucagon-like GLP1; Vasopressin AVPR; etc.
Integrins: alphaIIb/beta3 (Fibrinogen), alphaVbeta3 (Vitronectin), alpha4beta1, etc.
Heat Shock Proteins: HSP70, HSP90
Apoptosis: BCL-2, BCL-w, BCL-xl, MCL-1, IAP1, IAP2, XIAP, caspase-3, etc.
Pathways: Hedgehog Hh, Smo; WNT; WNT –beta-catenin; Notch, etc.

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