2297-0143 Screening compound: (2E)-3-(4-bromophenyl)-1-(2,6-dimethyl-4-phenylquinolin-3-yl)prop-2-en-1-one

2297-0143 Screening compound: (2E)-3-(4-bromophenyl)-1-(2,6-dimethyl-4-phenylquinolin-3-yl)prop-2-en-1-one
2297-0143 Screening compound: (2E)-3-(4-bromophenyl)-1-(2,6-dimethyl-4-phenylquinolin-3-yl)prop-2-en-1-one alternative view

Chemical Structure Depiction of ChemDiv screening compound 2297-0143
(2E)-3-(4-bromophenyl)-1-(2,6-dimethyl-4-phenylquinolin-3-yl)prop-2-en-1-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

2297-0143

Molecular Formula

C26H20BrNO (C26 H20 BrNO)

Compound Name

(2E)-3-(4-bromophenyl)-1-(2,6-dimethyl-4-phenylquinolin-3-yl)prop-2-en-1-one

IUPAC name

(2E)-3-(4-bromophenyl)-1-(26-dimethyl-4-phenylquinolin-3-yl)prop-2-en-1-one

SMILES

Cc1ccc2nc(C)c(C(/C=C/c(cc3)ccc3Br)=O)c(-c3ccccc3)c2c1

InChI

InChI=1S/C26H20BrNO/c1-17-8-14-23-22(16-17)26(20-6-4-3-5-7-20)25(18(2)28-23)24(29)15-11-19-9-12-21(27)13-10-19/h3-16H,1-2H3

InChI Key

DDDWLUNZOSDSIJ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD01152696

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

442.35

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

2

Partition Coefficient, logP

7.596

Distribution Coefficient, logD

7.596

Water Solubility, LogSw

-5.82

Polar Surface Area

21.850

Acid Dissociation Constant (pKa)

26.71

Base Dissociation Constant (pKb)

-0.11

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

7.70

2297-0143 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

?ysteine Targeted Covalent Library (39471 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with 2297-0143 chemical compound. It will be published here after verification.

Frequently Asked Questions

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What is the minimum amount of 2297-0143 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for 2297-0143
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for 2297-0143
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of 2297-0143 available by request