8007-1845 Screening compound: N-[4-chloro-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]-1-hydroxynaphthalene-2-carboxamide

8007-1845 Screening compound: N-[4-chloro-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]-1-hydroxynaphthalene-2-carboxamide
8007-1845 Screening compound: N-[4-chloro-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]-1-hydroxynaphthalene-2-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound 8007-1845
N-[4-chloro-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]-1-hydroxynaphthalene-2-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

8007-1845

Molecular Formula

C25H15ClN2O4 (C25 H15 ClN2 O4)

Compound Name

N-[4-chloro-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]-1-hydroxynaphthalene-2-carboxamide

IUPAC name

N-[4-chloro-3-(13-dioxo-23-dihydro-1H-isoindol-2-yl)phenyl]-1-hydroxynaphthalene-2-carboxamide

SMILES

Oc(c1ccccc1cc1)c1C(Nc(cc1)cc(N(C(c2c3cccc2)=O)C3=O)c1Cl)=O

InChI

InChI=1S/C25H15ClN2O4/c26-20-12-10-15(13-21(20)28-24(31)17-7-3-4-8-18(17)25(28)32)27-23(30)19-11-9-14-5-1-2-6-16(14)22(19)29/h1-13,29H,(H,27,30)

InChI Key

RQZAUKPTDOLJPL-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD00658236

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

442.86

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

5.167

Distribution Coefficient, logD

4.875

Water Solubility, LogSw

-5.43

Polar Surface Area

66.878

Acid Dissociation Constant (pKa)

7.42

Base Dissociation Constant (pKb)

-1.26

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

0.00

8007-1845 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Histone Deacetylases (HDAC) Targeted Library (9760 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Nervous system
  • Hemic and lymphatic
  • Endocrine
  • Immune system
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Mechanism of action:
  • Epigenetic
Targets:
  • Phosphatases

References: we are preparing a list of scientific research reports with 8007-1845 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound 8007-1845?
Check Price and Availability of 8007-1845, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of 8007-1845 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for 8007-1845
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for 8007-1845
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of 8007-1845 available by request