8010-1283 Screening compound: 3-chloro-5-(4-methylphenyl)-N-[3-(morpholin-4-yl)propyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

8010-1283 Screening compound: 3-chloro-5-(4-methylphenyl)-N-[3-(morpholin-4-yl)propyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
8010-1283 Screening compound: 3-chloro-5-(4-methylphenyl)-N-[3-(morpholin-4-yl)propyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound 8010-1283
3-chloro-5-(4-methylphenyl)-N-[3-(morpholin-4-yl)propyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

8010-1283

Molecular Formula

C22H23ClF3N5O2 (C22 H23 ClF3 N5 O2)

Compound Name

3-chloro-5-(4-methylphenyl)-N-[3-(morpholin-4-yl)propyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

IUPAC name

3-chloro-5-(4-methylphenyl)-N-[3-(morpholin-4-yl)propyl]-7-(trifluoromethyl)pyrazolo[15-a]pyrimidine-2-carboxamide

SMILES

Cc(cc1)ccc1-c(cc(C(F)(F)F)n1nc2C(NCCCN3CCOCC3)=O)nc1c2Cl

InChI

InChI=1S/C22H23ClF3N5O2/c1-14-3-5-15(6-4-14)16-13-17(22(24,25)26)31-20(28-16)18(23)19(29-31)21(32)27-7-2-8-30-9-11-33-12-10-30/h3-6,13H,2,7-12H2,1H3,(H,27,32)

InChI Key

YCMHDAMEYCOIBT-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD01529125

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

481.91

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.794

Distribution Coefficient, logD

3.406

Water Solubility, LogSw

-4.53

Polar Surface Area

55.860

Acid Dissociation Constant (pKa)

14.26

Base Dissociation Constant (pKb)

7.56

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

40.90

8010-1283 in Drug Discovery

Included in Screening Libraries

PI3K-Targeted Library (17255 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with 8010-1283 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound 8010-1283?
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What is the minimum amount of 8010-1283 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for 8010-1283
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for 8010-1283
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of 8010-1283 available by request