8010-2403 Screening compound: 4-(4-bromobenzoyl)-3-hydroxy-5-(2-methoxyphenyl)-1-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-2-one

8010-2403 Screening compound: 4-(4-bromobenzoyl)-3-hydroxy-5-(2-methoxyphenyl)-1-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-2-one
8010-2403 Screening compound: 4-(4-bromobenzoyl)-3-hydroxy-5-(2-methoxyphenyl)-1-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-2-one alternative view

Chemical Structure Depiction of ChemDiv screening compound 8010-2403
4-(4-bromobenzoyl)-3-hydroxy-5-(2-methoxyphenyl)-1-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-2-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

8010-2403

Molecular Formula

C25H17BrF3NO4 (C25 H17 BrF3 NO4)

Compound Name

4-(4-bromobenzoyl)-3-hydroxy-5-(2-methoxyphenyl)-1-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-2-one

IUPAC name

4-(4-bromobenzoyl)-3-hydroxy-5-(2-methoxyphenyl)-1-[3-(trifluoromethyl)phenyl]-25-dihydro-1H-pyrrol-2-one

SMILES

COc1c(C(C(C(c(cc2)ccc2Br)=O)=C(C2=O)O)N2c2cc(C(F)(F)F)ccc2)cccc1

InChI

InChI=1S/C25H17BrF3NO4/c1-34-19-8-3-2-7-18(19)21-20(22(31)14-9-11-16(26)12-10-14)23(32)24(33)30(21)17-6-4-5-15(13-17)25(27,28)29/h2-13,21,32H,1H3/t21-/m1/s1

InChI Key

KZILOVKZHBEZGJ-OAQYLSRUSA-N

MDL Number (MFCD)

MFCD01872713

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

532.31

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

5.874

Distribution Coefficient, logD

5.873

Water Solubility, LogSw

-5.65

Polar Surface Area

51.846

Acid Dissociation Constant (pKa)

9.95

Base Dissociation Constant (pKb)

-7.39

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

12.00

8010-2403 in Drug Discovery

Included in Screening Libraries

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with 8010-2403 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound 8010-2403?
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What is the minimum amount of 8010-2403 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for 8010-2403
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for 8010-2403
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of 8010-2403 available by request