8014-1377 Screening compound: 1-{[1,1'-biphenyl]-4-carbonyl}-4-[(2-methyl-1,3-thiazol-4-yl)methyl]piperazine

8014-1377 Screening compound: 1-{[1,1'-biphenyl]-4-carbonyl}-4-[(2-methyl-1,3-thiazol-4-yl)methyl]piperazine
8014-1377 Screening compound: 1-{[1,1'-biphenyl]-4-carbonyl}-4-[(2-methyl-1,3-thiazol-4-yl)methyl]piperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound 8014-1377
1-{[1,1'-biphenyl]-4-carbonyl}-4-[(2-methyl-1,3-thiazol-4-yl)methyl]piperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

8014-1377

Molecular Formula

C22H23N3OS (C22 H23 N3 OS)

Compound Name

1-{[1,1'-biphenyl]-4-carbonyl}-4-[(2-methyl-1,3-thiazol-4-yl)methyl]piperazine

IUPAC name

1-{[11'-biphenyl]-4-carbonyl}-4-[(2-methyl-13-thiazol-4-yl)methyl]piperazine

SMILES

Cc1nc(CN(CC2)CCN2C(c(cc2)ccc2-c2ccccc2)=O)cs1

InChI

InChI=1S/C22H23N3OS/c1-17-23-21(16-27-17)15-24-11-13-25(14-12-24)22(26)20-9-7-19(8-10-20)18-5-3-2-4-6-18/h2-10,16H,11-15H2,1H3

InChI Key

KLUPAENPOSVZOB-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD03767672

Chemical and Physical Properties

Saltdata

HCl

Molecular Weight

377.51

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

3.610

Distribution Coefficient, logD

3.605

Water Solubility, LogSw

-3.77

Polar Surface Area

30.463

Acid Dissociation Constant (pKa)

28.54

Base Dissociation Constant (pKb)

5.43

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

27.30

8014-1377 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

CNS Targets (44014 compounds)

Cardiovascular Library (22201 compounds)

GPCR Targeted Library (31838 compounds)

Akt-Targeted Library (14764 compounds)

Ion Channels Focused Library (26372 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Cardiovascular
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Nervous system
  • Cardiovascular
Targets:
  • GPCR
  • Kinases
  • Ion Channels
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with 8014-1377 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound 8014-1377?
Check Price and Availability of 8014-1377, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of 8014-1377 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for 8014-1377
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for 8014-1377
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of 8014-1377 available by request