C228-0618 Screening compound: 2-(5-chlorothiophen-2-yl)-N-(3-fluoro-4-methylphenyl)quinoline-4-carboxamide

C228-0618 Screening compound: 2-(5-chlorothiophen-2-yl)-N-(3-fluoro-4-methylphenyl)quinoline-4-carboxamide
C228-0618 Screening compound: 2-(5-chlorothiophen-2-yl)-N-(3-fluoro-4-methylphenyl)quinoline-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound C228-0618
2-(5-chlorothiophen-2-yl)-N-(3-fluoro-4-methylphenyl)quinoline-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

C228-0618

Molecular Formula

C21H14ClFN2OS (C21 H14 ClFN2 OS)

Compound Name

2-(5-chlorothiophen-2-yl)-N-(3-fluoro-4-methylphenyl)quinoline-4-carboxamide

IUPAC name

2-(5-chlorothiophen-2-yl)-N-(3-fluoro-4-methylphenyl)quinoline-4-carboxamide

SMILES

Cc(ccc(NC(c1cc(-c(s2)ccc2Cl)nc2ccccc12)=O)c1)c1F

InChI

InChI=1S/C21H14ClFN2OS/c1-12-6-7-13(10-16(12)23)24-21(26)15-11-18(19-8-9-20(22)27-19)25-17-5-3-2-4-14(15)17/h2-11H,1H3,(H,24,26)

InChI Key

GDUBZQVRZCDTHL-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14733689

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

396.87

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

3

Partition Coefficient, logP

6.576

Distribution Coefficient, logD

6.576

Water Solubility, LogSw

-6.23

Polar Surface Area

32.407

Acid Dissociation Constant (pKa)

10.89

Base Dissociation Constant (pKb)

1.20

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

4.80

C228-0618 in Drug Discovery

Included in Screening Libraries

Anti-Aging Library (44940 compounds)

PI3K-Targeted Library (17255 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Metabolic
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Mechanism of action:
  • Epigenetic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with C228-0618 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound C228-0618?
Check Price and Availability of C228-0618, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of C228-0618 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for C228-0618
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for C228-0618
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of C228-0618 available by request