CM4377-0358 Screening compound: 1-[3-(3-chlorophenyl)-1H-pyrazole-5-carbonyl]-3-[(1,5-dimethyl-1H-imidazol-2-yl)methoxy]piperidine

CM4377-0358 Screening compound: 1-[3-(3-chlorophenyl)-1H-pyrazole-5-carbonyl]-3-[(1,5-dimethyl-1H-imidazol-2-yl)methoxy]piperidine
CM4377-0358 Screening compound: 1-[3-(3-chlorophenyl)-1H-pyrazole-5-carbonyl]-3-[(1,5-dimethyl-1H-imidazol-2-yl)methoxy]piperidine alternative view

Chemical Structure Depiction of ChemDiv screening compound CM4377-0358
1-[3-(3-chlorophenyl)-1H-pyrazole-5-carbonyl]-3-[(1,5-dimethyl-1H-imidazol-2-yl)methoxy]piperidine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

CM4377-0358

Molecular Formula

C21H24ClN5O2 (C21 H24 ClN5 O2)

Compound Name

1-[3-(3-chlorophenyl)-1H-pyrazole-5-carbonyl]-3-[(1,5-dimethyl-1H-imidazol-2-yl)methoxy]piperidine

IUPAC name

1-[3-(3-chlorophenyl)-1H-pyrazole-5-carbonyl]-3-[(15-dimethyl-1H-imidazol-2-yl)methoxy]piperidine

SMILES

Cc1cnc(COC(CCC2)CN2C(c2cc(-c3cccc(Cl)c3)n[nH]2)=O)n1C

InChI

InChI=1S/C21H24ClN5O2/c1-14-11-23-20(26(14)2)13-29-17-7-4-8-27(12-17)21(28)19-10-18(24-25-19)15-5-3-6-16(22)9-15/h3,5-6,9-11,17H,4,7-8,12-13H2,1-2H3,(H,24,25)/t17-/m0/s1

InChI Key

URLBUUUQCLPWSR-KRWDZBQOSA-N

MDL Number (MFCD)

MFCD30459403

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

413.91

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

2.844

Distribution Coefficient, logD

1.179

Water Solubility, LogSw

-3.46

Polar Surface Area

59.294

Acid Dissociation Constant (pKa)

10.31

Base Dissociation Constant (pKb)

9.05

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

38.10

CM4377-0358 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

PPI Helix Turn 3D-Mimetics Library (71298 compounds)

Protein-Protein Interaction Library (218420 compounds)

Alpha-Helix Mimetics Library (25899 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
  • Mimetics

References: we are preparing a list of scientific research reports with CM4377-0358 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound CM4377-0358?
Check Price and Availability of CM4377-0358, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of CM4377-0358 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for CM4377-0358
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for CM4377-0358
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of CM4377-0358 available by request