D266-0221 Screening compound: N-[5-(dimethylcarbamoyl)-4-methyl-1,3-thiazol-2-yl]-3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboxamide

D266-0221 Screening compound: N-[5-(dimethylcarbamoyl)-4-methyl-1,3-thiazol-2-yl]-3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboxamide
D266-0221 Screening compound: N-[5-(dimethylcarbamoyl)-4-methyl-1,3-thiazol-2-yl]-3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound D266-0221
N-[5-(dimethylcarbamoyl)-4-methyl-1,3-thiazol-2-yl]-3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

D266-0221

Molecular Formula

C24H21N5O3S (C24 H21 N5 O3 S)

Compound Name

N-[5-(dimethylcarbamoyl)-4-methyl-1,3-thiazol-2-yl]-3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboxamide

IUPAC name

N-[5-(dimethylcarbamoyl)-4-methyl-13-thiazol-2-yl]-3-oxo-56-diphenyl-23-dihydropyridazine-4-carboxamide

SMILES

Cc1c(C(N(C)C)=O)sc(NC(C2=C(c3ccccc3)C(c3ccccc3)=NNC2=O)=O)n1

InChI

InChI=1S/C24H21N5O3S/c1-14-20(23(32)29(2)3)33-24(25-14)26-21(30)18-17(15-10-6-4-7-11-15)19(27-28-22(18)31)16-12-8-5-9-13-16/h4-13H,1-3H3,(H,28,31)(H,25,26,30)

InChI Key

SEOGJGVUXZQZQK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD06480040

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

459.53

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.179

Distribution Coefficient, logD

2.698

Water Solubility, LogSw

-3.46

Polar Surface Area

86.073

Acid Dissociation Constant (pKa)

7.09

Base Dissociation Constant (pKb)

2.29

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

12.50

D266-0221 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with D266-0221 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound D266-0221?
Check Price and Availability of D266-0221, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of D266-0221 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for D266-0221
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for D266-0221
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of D266-0221 available by request