D274-0059 Screening compound: N-[1-(4,6-dimethyl-2-pyrimidinyl)-4-piperidyl]-2-(2-thienyl)acetamide

D274-0059 Screening compound: N-[1-(4,6-dimethyl-2-pyrimidinyl)-4-piperidyl]-2-(2-thienyl)acetamide
D274-0059 Screening compound: N-[1-(4,6-dimethyl-2-pyrimidinyl)-4-piperidyl]-2-(2-thienyl)acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound D274-0059
N-[1-(4,6-dimethyl-2-pyrimidinyl)-4-piperidyl]-2-(2-thienyl)acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

D274-0059

Molecular Formula

C17H22N4OS (C17 H22 N4 OS)

Compound Name

N-[1-(4,6-dimethyl-2-pyrimidinyl)-4-piperidyl]-2-(2-thienyl)acetamide

IUPAC name

N-[1-(46-dimethylpyrimidin-2-yl)piperidin-4-yl]-2-(thiophen-2-yl)acetamide

SMILES

Cc1nc(N(CC2)CCC2NC(Cc2cccs2)=O)nc(C)c1

InChI

InChI=1S/C17H22N4OS/c1-12-10-13(2)19-17(18-12)21-7-5-14(6-8-21)20-16(22)11-15-4-3-9-23-15/h3-4,9-10,14H,5-8,11H2,1-2H3,(H,20,22)

InChI Key

OKAUGZQBDXXOKA-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14816382

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

330.45

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

2.036

Distribution Coefficient, logD

2.035

Water Solubility, LogSw

-2.62

Polar Surface Area

45.553

Acid Dissociation Constant (pKa)

16.10

Base Dissociation Constant (pKb)

4.86

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

47.06

D274-0059 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

GPCR Targeted Library (31838 compounds)

Purinergic Library (3321 compounds)

Soluble Diversity Library (15920 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Nervous system
  • Cardiovascular
  • Metabolic
Targets:
  • GPCR
  • GPCR
  • Ion Channels
Mechanism of action:
  • Receptor's ligands
  • Receptor's ligands

References: we are preparing a list of scientific research reports with D274-0059 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound D274-0059?
Check Price and Availability of D274-0059, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of D274-0059 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for D274-0059
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for D274-0059
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of D274-0059 available by request