E016-1488 Screening compound: 2-(4-methoxyphenyl)-7-methyl-5-{2-oxo-2-[4-(pyrimidin-2-yl)piperazin-1-yl]ethyl}-4H,5H-pyrazolo[1,5-d][1,2,4]triazin-4-one

E016-1488 Screening compound: 2-(4-methoxyphenyl)-7-methyl-5-{2-oxo-2-[4-(pyrimidin-2-yl)piperazin-1-yl]ethyl}-4H,5H-pyrazolo[1,5-d][1,2,4]triazin-4-one
E016-1488 Screening compound: 2-(4-methoxyphenyl)-7-methyl-5-{2-oxo-2-[4-(pyrimidin-2-yl)piperazin-1-yl]ethyl}-4H,5H-pyrazolo[1,5-d][1,2,4]triazin-4-one alternative view

Chemical Structure Depiction of ChemDiv screening compound E016-1488
2-(4-methoxyphenyl)-7-methyl-5-{2-oxo-2-[4-(pyrimidin-2-yl)piperazin-1-yl]ethyl}-4H,5H-pyrazolo[1,5-d][1,2,4]triazin-4-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E016-1488

Molecular Formula

C23H24N8O3 (C23 H24 N8 O3)

Compound Name

2-(4-methoxyphenyl)-7-methyl-5-{2-oxo-2-[4-(pyrimidin-2-yl)piperazin-1-yl]ethyl}-4H,5H-pyrazolo[1,5-d][1,2,4]triazin-4-one

IUPAC name

2-(4-methoxyphenyl)-7-methyl-5-{2-oxo-2-[4-(pyrimidin-2-yl)piperazin-1-yl]ethyl}-4H5H-pyrazolo[15-d][124]triazin-4-one

SMILES

CC(n(c1c2)nc2-c(cc2)ccc2OC)=NN(CC(N(CC2)CCN2c2ncccn2)=O)C1=O

InChI

InChI=1S/C23H24N8O3/c1-16-26-30(15-21(32)28-10-12-29(13-11-28)23-24-8-3-9-25-23)22(33)20-14-19(27-31(16)20)17-4-6-18(34-2)7-5-17/h3-9,14H,10-13,15H2,1-2H3

InChI Key

UHFOMJXDFNZLRC-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14838732

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

460.5

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

11

Partition Coefficient, logP

2.004

Distribution Coefficient, logD

2.004

Water Solubility, LogSw

-2.44

Polar Surface Area

86.325

Acid Dissociation Constant (pKa)

17.24

Base Dissociation Constant (pKb)

2.67

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

30.40

E016-1488 in Drug Discovery

Included in Screening Libraries

Akt-Targeted Library (14764 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with E016-1488 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E016-1488?
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What is the minimum amount of E016-1488 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E016-1488
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E016-1488
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E016-1488 available by request