E136-1764 Screening compound: N-[5-(2-ethoxyethyl)-1,3,4-thiadiazol-2-yl]-1,3-diphenyl-1H-pyrazole-4-carboxamide

E136-1764 Screening compound: N-[5-(2-ethoxyethyl)-1,3,4-thiadiazol-2-yl]-1,3-diphenyl-1H-pyrazole-4-carboxamide
E136-1764 Screening compound: N-[5-(2-ethoxyethyl)-1,3,4-thiadiazol-2-yl]-1,3-diphenyl-1H-pyrazole-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E136-1764
N-[5-(2-ethoxyethyl)-1,3,4-thiadiazol-2-yl]-1,3-diphenyl-1H-pyrazole-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E136-1764

Molecular Formula

C22H21N5O2S (C22 H21 N5 O2 S)

Compound Name

N-[5-(2-ethoxyethyl)-1,3,4-thiadiazol-2-yl]-1,3-diphenyl-1H-pyrazole-4-carboxamide

IUPAC name

N-[5-(2-ethoxyethyl)-134-thiadiazol-2-yl]-13-diphenyl-1H-pyrazole-4-carboxamide

SMILES

CCOCCc1nnc(NC(c2cn(-c3ccccc3)nc2-c2ccccc2)=O)s1

InChI

InChI=1S/C22H21N5O2S/c1-2-29-14-13-19-24-25-22(30-19)23-21(28)18-15-27(17-11-7-4-8-12-17)26-20(18)16-9-5-3-6-10-16/h3-12,15H,2,13-14H2,1H3,(H,23,25,28)

InChI Key

JNKYFZVJXDZKOT-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14841320

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

419.51

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.095

Distribution Coefficient, logD

4.063

Water Solubility, LogSw

-4.11

Polar Surface Area

69.980

Acid Dissociation Constant (pKa)

8.52

Base Dissociation Constant (pKb)

-2.75

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

18.20

E136-1764 in Drug Discovery

Included in Screening Libraries

Anti-Aging Library (44940 compounds)

Aurora A-B Kinases Targeted Library (9426 compounds)

Type II Kinase Inhibitors Library (6956 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Metabolic
  • Immune system
  • Cancer
  • Digestive system
  • Male
  • Female
  • Hemic and lymphatic
  • Digestive system
  • Hemic and lymphatic
  • Endocrine
Mechanism of action:
  • Epigenetic
Targets:
  • Kinases
  • Kinases

References: we are preparing a list of scientific research reports with E136-1764 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E136-1764?
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What is the minimum amount of E136-1764 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E136-1764
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E136-1764
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E136-1764 available by request