E146-0254 Screening compound: 1-{4H-chromeno[3,4-d][1,2]oxazole-3-carbonyl}-4-methylpiperazine

E146-0254 Screening compound: 1-{4H-chromeno[3,4-d][1,2]oxazole-3-carbonyl}-4-methylpiperazine
E146-0254 Screening compound: 1-{4H-chromeno[3,4-d][1,2]oxazole-3-carbonyl}-4-methylpiperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound E146-0254
1-{4H-chromeno[3,4-d][1,2]oxazole-3-carbonyl}-4-methylpiperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E146-0254

Molecular Formula

C16H17N3O3 (C16 H17 N3 O3)

Compound Name

1-{4H-chromeno[3,4-d][1,2]oxazole-3-carbonyl}-4-methylpiperazine

IUPAC name

1-{4H-chromeno[34-d][12]oxazole-3-carbonyl}-4-methylpiperazine

SMILES

CN(CC1)CCN1C(c1noc-2c1COc1c2cccc1)=O

InChI

InChI=1S/C16H17N3O3/c1-18-6-8-19(9-7-18)16(20)14-12-10-21-13-5-3-2-4-11(13)15(12)22-17-14/h2-5H,6-10H2,1H3

InChI Key

MVZIBLCOLQIRRO-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14842520

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

299.33

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

2.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

1.337

Distribution Coefficient, logD

1.205

Water Solubility, LogSw

-2.06

Polar Surface Area

50.894

Acid Dissociation Constant (pKa)

19.32

Base Dissociation Constant (pKb)

6.95

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

37.50

E146-0254 in Drug Discovery

Included in Screening Libraries

CNS BBB Library (22607 compounds)

CNS MPO Library (28609 compounds)

GPCR Targeted Library (31838 compounds)

Soluble Diversity Library (15920 compounds)

Epitranscriptome Focused Small Molecule Library (20952 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Nervous system
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Nervous system
  • Hemic and lymphatic
  • Congenital
  • Metabolic
Targets:
  • GPCR
Mechanism of action:
  • Receptor's ligands
  • Epigenetic

References: we are preparing a list of scientific research reports with E146-0254 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E146-0254?
Check Price and Availability of E146-0254, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E146-0254 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E146-0254
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E146-0254
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E146-0254 available by request