E146-1306 Screening compound: 1,3-dimethyl 5-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-amido}benzene-1,3-dicarboxylate

E146-1306 Screening compound: 1,3-dimethyl 5-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-amido}benzene-1,3-dicarboxylate
E146-1306 Screening compound: 1,3-dimethyl 5-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-amido}benzene-1,3-dicarboxylate alternative view

Chemical Structure Depiction of ChemDiv screening compound E146-1306
1,3-dimethyl 5-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-amido}benzene-1,3-dicarboxylate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E146-1306

Molecular Formula

C22H19N3O6 (C22 H19 N3 O6)

Compound Name

1,3-dimethyl 5-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-amido}benzene-1,3-dicarboxylate

IUPAC name

13-dimethyl 5-{1-methyl-1H4H-chromeno[43-c]pyrazole-3-amido}benzene-13-dicarboxylate

SMILES

Cn1nc(C(Nc2cc(C(OC)=O)cc(C(OC)=O)c2)=O)c2c1-c(cccc1)c1OC2

InChI

InChI=1S/C22H19N3O6/c1-25-19-15-6-4-5-7-17(15)31-11-16(19)18(24-25)20(26)23-14-9-12(21(27)29-2)8-13(10-14)22(28)30-3/h4-10H,11H2,1-3H3,(H,23,26)

InChI Key

YLFVWBWVVCSWOW-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14843052

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

421.41

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

3.379

Distribution Coefficient, logD

3.379

Water Solubility, LogSw

-3.94

Polar Surface Area

88.450

Acid Dissociation Constant (pKa)

10.64

Base Dissociation Constant (pKb)

-1.56

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

18.20

E146-1306 in Drug Discovery

Included in Screening Libraries

Anti-Inflammatory Library (24602 compounds)

Antiviral Annotated Library (21441 compounds)

Antiviral Library (67538 compounds)

Protein-Protein Interaction Library (218420 compounds)

SH2 Library (10483 compounds)

ChemoGenomic Annotated Library for Phenotypic Screening (89798 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Immune system
  • Antiviral
  • Infections
  • Immune system
  • Cancer
  • Endocrine
  • Immune system
Mechanism of action:
  • PPI modulators
  • PPI modulators
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E146-1306 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E146-1306?
Check Price and Availability of E146-1306, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E146-1306 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E146-1306
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E146-1306
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E146-1306 available by request