E475-1284 Screening compound: N~1~-[3-(3-fluorophenyl)-5-isoxazolyl]-3-(4-methylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepine-1-carboxamide

E475-1284 Screening compound: N~1~-[3-(3-fluorophenyl)-5-isoxazolyl]-3-(4-methylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepine-1-carboxamide
E475-1284 Screening compound: N~1~-[3-(3-fluorophenyl)-5-isoxazolyl]-3-(4-methylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepine-1-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E475-1284
N~1~-[3-(3-fluorophenyl)-5-isoxazolyl]-3-(4-methylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepine-1-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E475-1284

Molecular Formula

C25H23FN4O2 (C25 H23 FN4 O2)

Compound Name

N~1~-[3-(3-fluorophenyl)-5-isoxazolyl]-3-(4-methylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepine-1-carboxamide

IUPAC name

n/a

SMILES

Cc(cc1)ccc1-c1nc(C(Nc2cc(-c3cccc(F)c3)no2)=O)c2n1CCCCC2

InChI

InChI=1S/C25H23FN4O2/c1-16-9-11-17(12-10-16)24-28-23(21-8-3-2-4-13-30(21)24)25(31)27-22-15-20(29-32-22)18-6-5-7-19(26)14-18/h5-7,9-12,14-15H,2-4,8,13H2,1H3,(H,27,31)

InChI Key

SYFGHWRHLDCOAC-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14855817

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

430.48

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

6.127

Distribution Coefficient, logD

6.126

Water Solubility, LogSw

-5.34

Polar Surface Area

56.451

Acid Dissociation Constant (pKa)

10.18

Base Dissociation Constant (pKb)

3.39

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

24.00

E475-1284 in Drug Discovery

Included in Screening Libraries

Protein-Protein Interaction Library (218420 compounds)

Aurora A-B Kinases Targeted Library (9426 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
Therapeutical areas:
  • Cancer
  • Digestive system
  • Male
  • Female
  • Hemic and lymphatic
Targets:
  • Kinases
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with E475-1284 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E475-1284?
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What is the minimum amount of E475-1284 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E475-1284
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E475-1284
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E475-1284 available by request