E643-1970 Screening compound: 1-[4-(2-fluorophenyl)piperazin-1-yl]-2-{3H-imidazo[4,5-b]pyridin-2-ylsulfanyl}ethan-1-one

E643-1970 Screening compound: 1-[4-(2-fluorophenyl)piperazin-1-yl]-2-{3H-imidazo[4,5-b]pyridin-2-ylsulfanyl}ethan-1-one
E643-1970 Screening compound: 1-[4-(2-fluorophenyl)piperazin-1-yl]-2-{3H-imidazo[4,5-b]pyridin-2-ylsulfanyl}ethan-1-one alternative view

Chemical Structure Depiction of ChemDiv screening compound E643-1970
1-[4-(2-fluorophenyl)piperazin-1-yl]-2-{3H-imidazo[4,5-b]pyridin-2-ylsulfanyl}ethan-1-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E643-1970

Molecular Formula

C18H18FN5OS (C18 H18 FN5 OS)

Compound Name

1-[4-(2-fluorophenyl)piperazin-1-yl]-2-{3H-imidazo[4,5-b]pyridin-2-ylsulfanyl}ethan-1-one

IUPAC name

1-[4-(2-fluorophenyl)piperazin-1-yl]-2-{3H-imidazo[45-b]pyridin-2-ylsulfanyl}ethan-1-one

SMILES

O=C(CSc([nH]1)nc2c1nccc2)N(CC1)CCN1c(cccc1)c1F

InChI

InChI=1S/C18H18FN5OS/c19-13-4-1-2-6-15(13)23-8-10-24(11-9-23)16(25)12-26-18-21-14-5-3-7-20-17(14)22-18/h1-7H,8-12H2,(H,20,21,22)

InChI Key

MVUVIUHJWBMBIX-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14907244

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

371.44

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

2.051

Distribution Coefficient, logD

2.044

Water Solubility, LogSw

-2.42

Polar Surface Area

47.706

Acid Dissociation Constant (pKa)

9.16

Base Dissociation Constant (pKb)

4.24

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

27.80

E643-1970 in Drug Discovery

Included in Screening Libraries

Akt-Targeted Library (14764 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with E643-1970 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E643-1970?
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What is the minimum amount of E643-1970 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E643-1970
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E643-1970
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E643-1970 available by request