E922-1686 Screening compound: 2-{4-[1-(3-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazin-1-yl}pyrimidine

E922-1686 Screening compound: 2-{4-[1-(3-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazin-1-yl}pyrimidine
E922-1686 Screening compound: 2-{4-[1-(3-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazin-1-yl}pyrimidine alternative view

Chemical Structure Depiction of ChemDiv screening compound E922-1686
2-{4-[1-(3-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazin-1-yl}pyrimidine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E922-1686

Molecular Formula

C23H26FN7O (C23 H26 FN7 O)

Compound Name

2-{4-[1-(3-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazin-1-yl}pyrimidine

IUPAC name

2-{4-[1-(3-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazin-1-yl}pyrimidine

SMILES

O=C(c1c(C2CCNCC2)n(-c2cccc(F)c2)nc1)N(CC1)CCN1c1ncccn1

InChI

InChI=1S/C23H26FN7O/c24-18-3-1-4-19(15-18)31-21(17-5-9-25-10-6-17)20(16-28-31)22(32)29-11-13-30(14-12-29)23-26-7-2-8-27-23/h1-4,7-8,15-17,25H,5-6,9-14H2

InChI Key

NEXTVXMMYFDRFT-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14928631

Chemical and Physical Properties

Saltdata

HCl

Molecular Weight

435.5

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

1.669

Distribution Coefficient, logD

-1.812

Water Solubility, LogSw

-2.12

Polar Surface Area

63.485

Acid Dissociation Constant (pKa)

21.00

Base Dissociation Constant (pKb)

10.88

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

39.10

E922-1686 in Drug Discovery

Included in Screening Libraries

GPCR Targeted Library (31838 compounds)

KRAS-Targeted Library (16000 compounds)

Protein-Protein Interaction Library (218420 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Immune system
Targets:
  • GPCR
  • Kinases
Mechanism of action:
  • Receptor's ligands
  • PPI modulators
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E922-1686 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E922-1686?
Check Price and Availability of E922-1686, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E922-1686 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E922-1686
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E922-1686
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E922-1686 available by request