E947-0159 Screening compound: 5-[4-(4-chlorophenyl)piperazine-1-carbonyl]-3,6-dimethyl-3H,4H-furo[2,3-d]pyrimidin-4-one

E947-0159 Screening compound: 5-[4-(4-chlorophenyl)piperazine-1-carbonyl]-3,6-dimethyl-3H,4H-furo[2,3-d]pyrimidin-4-one
E947-0159 Screening compound: 5-[4-(4-chlorophenyl)piperazine-1-carbonyl]-3,6-dimethyl-3H,4H-furo[2,3-d]pyrimidin-4-one alternative view

Chemical Structure Depiction of ChemDiv screening compound E947-0159
5-[4-(4-chlorophenyl)piperazine-1-carbonyl]-3,6-dimethyl-3H,4H-furo[2,3-d]pyrimidin-4-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E947-0159

Molecular Formula

C19H19ClN4O3 (C19 H19 ClN4 O3)

Compound Name

5-[4-(4-chlorophenyl)piperazine-1-carbonyl]-3,6-dimethyl-3H,4H-furo[2,3-d]pyrimidin-4-one

IUPAC name

5-[4-(4-chlorophenyl)piperazine-1-carbonyl]-36-dimethyl-3H4H-furo[23-d]pyrimidin-4-one

SMILES

Cc1c(C(N(CC2)CCN2c(cc2)ccc2Cl)=O)c(C(N(C)C=N2)=O)c2o1

InChI

InChI=1S/C19H19ClN4O3/c1-12-15(16-17(27-12)21-11-22(2)18(16)25)19(26)24-9-7-23(8-10-24)14-5-3-13(20)4-6-14/h3-6,11H,7-10H2,1-2H3

InChI Key

SWUVNSKRINIFTH-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD26965227

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

386.84

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

1.684

Distribution Coefficient, logD

1.684

Water Solubility, LogSw

-2.80

Polar Surface Area

53.617

Acid Dissociation Constant (pKa)

28.00

Base Dissociation Constant (pKb)

1.23

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

31.60

E947-0159 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

Anti-Aging Library (44940 compounds)

PI3K-Targeted Library (17255 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Metabolic
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Mechanism of action:
  • Epigenetic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with E947-0159 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E947-0159?
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What is the minimum amount of E947-0159 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E947-0159
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E947-0159
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E947-0159 available by request