E959-1364 Screening compound: 1-{[5-(6-oxo-1,6-dihydropyridazin-3-yl)thiophen-2-yl]sulfonyl}-N-(2,4,6-trimethylphenyl)pyrrolidine-2-carboxamide

E959-1364 Screening compound: 1-{[5-(6-oxo-1,6-dihydropyridazin-3-yl)thiophen-2-yl]sulfonyl}-N-(2,4,6-trimethylphenyl)pyrrolidine-2-carboxamide
E959-1364 Screening compound: 1-{[5-(6-oxo-1,6-dihydropyridazin-3-yl)thiophen-2-yl]sulfonyl}-N-(2,4,6-trimethylphenyl)pyrrolidine-2-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E959-1364
1-{[5-(6-oxo-1,6-dihydropyridazin-3-yl)thiophen-2-yl]sulfonyl}-N-(2,4,6-trimethylphenyl)pyrrolidine-2-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E959-1364

Molecular Formula

C22H24N4O4S2 (C22 H24 N4 O4 S2)

Compound Name

1-{[5-(6-oxo-1,6-dihydropyridazin-3-yl)thiophen-2-yl]sulfonyl}-N-(2,4,6-trimethylphenyl)pyrrolidine-2-carboxamide

IUPAC name

1-{[5-(6-oxo-16-dihydropyridazin-3-yl)thiophen-2-yl]sulfonyl}-N-(246-trimethylphenyl)pyrrolidine-2-carboxamide

SMILES

Cc(cc1C)cc(C)c1NC(C(CCC1)N1S(c1ccc(C(C=C2)=NNC2=O)s1)(=O)=O)=O

InChI

InChI=1S/C22H24N4O4S2/c1-13-11-14(2)21(15(3)12-13)23-22(28)17-5-4-10-26(17)32(29,30)20-9-7-18(31-20)16-6-8-19(27)25-24-16/h6-9,11-12,17H,4-5,10H2,1-3H3,(H,23,28)(H,25,27)/t17-/m0/s1

InChI Key

RPTUNBNVVNFVJP-KRWDZBQOSA-N

MDL Number (MFCD)

MFCD14933277

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

472.59

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.287

Distribution Coefficient, logD

3.287

Water Solubility, LogSw

-3.37

Polar Surface Area

92.638

Acid Dissociation Constant (pKa)

10.90

Base Dissociation Constant (pKb)

-0.21

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

31.80

E959-1364 in Drug Discovery

Included in Screening Libraries

Antiviral HBV Library (10007 compounds)

Antiviral Library (67538 compounds)

KRAS-Targeted Library (16000 compounds)

Anti-HIV1 Library (19540 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Antiviral
  • Infections
  • Immune system
  • Antiviral
  • Infections
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Antiviral
  • Infections
  • Immune system
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with E959-1364 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E959-1364?
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What is the minimum amount of E959-1364 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E959-1364
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E959-1364
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E959-1364 available by request