E963-0255 Screening compound: 1-(2-chlorobenzyl)-3'-(3-fluoro-4-methylphenyl)-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione 1',1'-dioxide

E963-0255 Screening compound: 1-(2-chlorobenzyl)-3'-(3-fluoro-4-methylphenyl)-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione 1',1'-dioxide
E963-0255 Screening compound: 1-(2-chlorobenzyl)-3'-(3-fluoro-4-methylphenyl)-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione 1',1'-dioxide alternative view

Chemical Structure Depiction of ChemDiv screening compound E963-0255
1-(2-chlorobenzyl)-3'-(3-fluoro-4-methylphenyl)-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione 1',1'-dioxide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E963-0255

Molecular Formula

C24H18ClFN2O4S (C24 H18 ClFN2 O4 S)

Compound Name

1-(2-chlorobenzyl)-3'-(3-fluoro-4-methylphenyl)-4'H-spiro[indole-3,2'-[1,3]thiazolidine]-2,4'(1H)-dione 1',1'-dioxide

IUPAC name

1-[(2-chlorophenyl)methyl]-3'-(3-fluoro-4-methylphenyl)-12-dihydrospiro[indole-32'-[1lambda63]thiazolidine]-1'1'24'-tetrone

SMILES

Cc(ccc(N(C(c(cccc1)c1N1Cc(cccc2)c2Cl)(C1=O)S(C1)(=O)=O)C1=O)c1)c1F

InChI

InChI=1S/C24H18ClFN2O4S/c1-15-10-11-17(12-20(15)26)28-22(29)14-33(31,32)24(28)18-7-3-5-9-21(18)27(23(24)30)13-16-6-2-4-8-19(16)25/h2-12H,13-14H2,1H3/t24-/m0/s1

InChI Key

QYQJAZIXPJHOCC-DEOSSOPVSA-N

MDL Number (MFCD)

MFCD09248621

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

484.94

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.194

Distribution Coefficient, logD

0.125

Water Solubility, LogSw

-4.47

Polar Surface Area

59.535

Acid Dissociation Constant (pKa)

3.33

Base Dissociation Constant (pKb)

-8.06

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

16.70

E963-0255 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Antiviral Annotated Library (21441 compounds)

Protein-Protein Interaction Library (218420 compounds)

Spiro Library (21655 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

?ysteine Targeted Covalent Library (39471 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds
  • Cyclic compounds

References: we are preparing a list of scientific research reports with E963-0255 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E963-0255?
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What is the minimum amount of E963-0255 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E963-0255
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E963-0255
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E963-0255 available by request