F144-0189 Screening compound: 2-(4-{1-[(5-formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}phenyl)-N-propylacetamide

F144-0189 Screening compound: 2-(4-{1-[(5-formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}phenyl)-N-propylacetamide
F144-0189 Screening compound: 2-(4-{1-[(5-formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}phenyl)-N-propylacetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound F144-0189
2-(4-{1-[(5-formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}phenyl)-N-propylacetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

F144-0189

Molecular Formula

C28H27N3O5 (C28 H27 N3 O5)

Compound Name

2-(4-{1-[(5-formyl-2-methoxyphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl}phenyl)-N-propylacetamide

IUPAC name

2-(4-{1-[(5-formyl-2-methoxyphenyl)methyl]-24-dioxo-1234-tetrahydroquinazolin-3-yl}phenyl)-N-propylacetamide

SMILES

CCCNC(Cc(cc1)ccc1N(C(c(cccc1)c1N1Cc(cc(C=O)cc2)c2OC)=O)C1=O)=O

InChI

InChI=1S/C28H27N3O5/c1-3-14-29-26(33)16-19-8-11-22(12-9-19)31-27(34)23-6-4-5-7-24(23)30(28(31)35)17-21-15-20(18-32)10-13-25(21)36-2/h4-13,15,18H,3,14,16-17H2,1-2H3,(H,29,33)

InChI Key

UCXZBWGSSYJUFG-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27104369

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

485.54

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

10.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

2.371

Distribution Coefficient, logD

2.371

Water Solubility, LogSw

-3.12

Polar Surface Area

76.758

Acid Dissociation Constant (pKa)

15.09

Base Dissociation Constant (pKb)

0.74

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

21.40

F144-0189 in Drug Discovery

Included in Screening Libraries

Covalent Inhibitors Library (7986 compounds)

?ysteine Targeted Covalent Library (39471 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Structure:
  • Cyclic compounds
  • 3D
  • Fragments
Therapeutical areas:
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Targets:
  • Phosphatases

References: we are preparing a list of scientific research reports with F144-0189 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound F144-0189?
Check Price and Availability of F144-0189, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of F144-0189 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for F144-0189
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for F144-0189
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of F144-0189 available by request