G219-4459 Screening compound: 2-({1,3-dimethyl-4-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl}oxy)-N-[(4-methylphenyl)methyl]acetamide

G219-4459 Screening compound: 2-({1,3-dimethyl-4-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl}oxy)-N-[(4-methylphenyl)methyl]acetamide
G219-4459 Screening compound: 2-({1,3-dimethyl-4-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl}oxy)-N-[(4-methylphenyl)methyl]acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G219-4459
2-({1,3-dimethyl-4-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl}oxy)-N-[(4-methylphenyl)methyl]acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G219-4459

Molecular Formula

C24H24N4O2 (C24 H24 N4 O2)

Compound Name

2-({1,3-dimethyl-4-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl}oxy)-N-[(4-methylphenyl)methyl]acetamide

IUPAC name

2-({13-dimethyl-4-phenyl-1H-pyrazolo[34-b]pyridin-6-yl}oxy)-N-[(4-methylphenyl)methyl]acetamide

SMILES

Cc1nn(C)c2c1c(-c1ccccc1)cc(OCC(NCc1ccc(C)cc1)=O)n2

InChI

InChI=1S/C24H24N4O2/c1-16-9-11-18(12-10-16)14-25-21(29)15-30-22-13-20(19-7-5-4-6-8-19)23-17(2)27-28(3)24(23)26-22/h4-13H,14-15H2,1-3H3,(H,25,29)

InChI Key

GFOWWESSWIPMRA-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27211430

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

400.48

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.017

Distribution Coefficient, logD

4.017

Water Solubility, LogSw

-4.39

Polar Surface Area

55.383

Acid Dissociation Constant (pKa)

13.23

Base Dissociation Constant (pKb)

0.52

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

20.80

G219-4459 in Drug Discovery

Included in Screening Libraries

Glucocorticoid receptors Library (4806 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Nervous system
  • Hemic and lymphatic
  • Congenital
  • Metabolic
  • Endocrine
Targets:
  • Nuclear receptors
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with G219-4459 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G219-4459?
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What is the minimum amount of G219-4459 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G219-4459
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G219-4459
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G219-4459 available by request