G221-0251 Screening compound: 1-[(2-chloro-4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-4-cyclohexylpiperazine

G221-0251 Screening compound: 1-[(2-chloro-4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-4-cyclohexylpiperazine
G221-0251 Screening compound: 1-[(2-chloro-4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-4-cyclohexylpiperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound G221-0251
1-[(2-chloro-4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-4-cyclohexylpiperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G221-0251

Molecular Formula

C25H28ClFN4O (C25 H28 ClFN4 O)

Compound Name

1-[(2-chloro-4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-4-cyclohexylpiperazine

IUPAC name

1-[(2-chloro-4-fluorophenyl)(5-phenyl-134-oxadiazol-2-yl)methyl]-4-cyclohexylpiperazine

SMILES

Fc1cc(Cl)c(C(c2nnc(-c3ccccc3)o2)N(CC2)CCN2C2CCCCC2)cc1

InChI

InChI=1S/C25H28ClFN4O/c26-22-17-19(27)11-12-21(22)23(25-29-28-24(32-25)18-7-3-1-4-8-18)31-15-13-30(14-16-31)20-9-5-2-6-10-20/h1,3-4,7-8,11-12,17,20,23H,2,5-6,9-10,13-16H2/t23-/m1/s1

InChI Key

DYRFJHWVOYPLRH-HSZRJFAPSA-N

MDL Number (MFCD)

MFCD14988508

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

454.97

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

5.855

Distribution Coefficient, logD

5.095

Water Solubility, LogSw

-6.14

Polar Surface Area

36.601

Acid Dissociation Constant (pKa)

26.61

Base Dissociation Constant (pKb)

8.08

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

44.00

G221-0251 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

CNS BBB Library (22607 compounds)

DGK Inhibitors Library (10558 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Cancer
  • Digestive system
  • Hemic and lymphatic
  • Skin
  • Metabolic
  • Immune system
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with G221-0251 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G221-0251?
Check Price and Availability of G221-0251, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of G221-0251 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G221-0251
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G221-0251
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G221-0251 available by request