G394-0143 Screening compound: N-[2-(4-chlorophenyl)ethyl]-5-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-d]pyrimidine-6-carboxamide

G394-0143 Screening compound: N-[2-(4-chlorophenyl)ethyl]-5-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-d]pyrimidine-6-carboxamide
G394-0143 Screening compound: N-[2-(4-chlorophenyl)ethyl]-5-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-d]pyrimidine-6-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G394-0143
N-[2-(4-chlorophenyl)ethyl]-5-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-d]pyrimidine-6-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G394-0143

Molecular Formula

C21H24ClN5OS (C21 H24 ClN5 OS)

Compound Name

N-[2-(4-chlorophenyl)ethyl]-5-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-d]pyrimidine-6-carboxamide

IUPAC name

N-[2-(4-chlorophenyl)ethyl]-5-methyl-4-(4-methylpiperazin-1-yl)thieno[23-d]pyrimidine-6-carboxamide

SMILES

Cc1c(C(NCCc(cc2)ccc2Cl)=O)sc2c1c(N1CCN(C)CC1)ncn2

InChI

InChI=1S/C21H24ClN5OS/c1-14-17-19(27-11-9-26(2)10-12-27)24-13-25-21(17)29-18(14)20(28)23-8-7-15-3-5-16(22)6-4-15/h3-6,13H,7-12H2,1-2H3,(H,23,28)

InChI Key

CZZVLCWTJHTLMW-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15007260

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

429.97

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.716

Distribution Coefficient, logD

3.252

Water Solubility, LogSw

-4.27

Polar Surface Area

52.270

Acid Dissociation Constant (pKa)

12.53

Base Dissociation Constant (pKb)

7.68

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

38.10

G394-0143 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

Nucleic Acid Ligands (8311 compounds)

Protein-Protein Interaction Library (218420 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Ion Channels Focused Library (26372 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Infections
  • Cancer
  • Musculoskeletal
  • Nervous system
  • Hemic and lymphatic
  • Immune system
  • Immune system
  • Nervous system
  • Cardiovascular
Targets:
  • Kinases
  • Ion Channels
Mechanism of action:
  • PPI modulators
  • Receptor's ligands

References: we are preparing a list of scientific research reports with G394-0143 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G394-0143?
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What is the minimum amount of G394-0143 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G394-0143
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G394-0143
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G394-0143 available by request