G421-1132 Screening compound: 1-{6-[(4-ethoxy-3-methoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}-4-(pyridin-2-yl)piperazine

G421-1132 Screening compound: 1-{6-[(4-ethoxy-3-methoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}-4-(pyridin-2-yl)piperazine
G421-1132 Screening compound: 1-{6-[(4-ethoxy-3-methoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}-4-(pyridin-2-yl)piperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound G421-1132
1-{6-[(4-ethoxy-3-methoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}-4-(pyridin-2-yl)piperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G421-1132

Molecular Formula

C26H32N6O2 (C26 H32 N6 O2)

Compound Name

1-{6-[(4-ethoxy-3-methoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}-4-(pyridin-2-yl)piperazine

IUPAC name

1-{6-[(4-ethoxy-3-methoxyphenyl)methyl]-5H6H7H8H-pyrido[43-d]pyrimidin-2-yl}-4-(pyridin-2-yl)piperazine

SMILES

CCOc(ccc(CN(CC1)Cc2c1nc(N(CC1)CCN1c1ncccc1)nc2)c1)c1OC

InChI

InChI=1S/C26H32N6O2/c1-3-34-23-8-7-20(16-24(23)33-2)18-30-11-9-22-21(19-30)17-28-26(29-22)32-14-12-31(13-15-32)25-6-4-5-10-27-25/h4-8,10,16-17H,3,9,11-15,18-19H2,1-2H3

InChI Key

SGFSNGOIPVENKT-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15012627

Chemical and Physical Properties

Saltdata

2HCl

Molecular Weight

460.58

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.308

Distribution Coefficient, logD

3.135

Water Solubility, LogSw

-3.16

Polar Surface Area

53.218

Acid Dissociation Constant (pKa)

20.66

Base Dissociation Constant (pKb)

7.09

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

42.30

G421-1132 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Selective Target Activity Profiling Library (14702 compounds)

SmartTM Library (51161 compounds)

Akt-Targeted Library (14764 compounds)

ChemoGenomic Annotated Library for Phenotypic Screening (89798 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with G421-1132 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G421-1132?
Check Price and Availability of G421-1132, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of G421-1132 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G421-1132
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G421-1132
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G421-1132 available by request