G574-0272 Screening compound: N-{2-[2-(3-fluorophenyl)-[1,2,4]triazolo[3,2-b][1,3]thiazol-6-yl]ethyl}-3,5-dimethylbenzamide

G574-0272 Screening compound: N-{2-[2-(3-fluorophenyl)-[1,2,4]triazolo[3,2-b][1,3]thiazol-6-yl]ethyl}-3,5-dimethylbenzamide
G574-0272 Screening compound: N-{2-[2-(3-fluorophenyl)-[1,2,4]triazolo[3,2-b][1,3]thiazol-6-yl]ethyl}-3,5-dimethylbenzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G574-0272
N-{2-[2-(3-fluorophenyl)-[1,2,4]triazolo[3,2-b][1,3]thiazol-6-yl]ethyl}-3,5-dimethylbenzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G574-0272

Molecular Formula

C21H19FN4OS (C21 H19 FN4 OS)

Compound Name

N-{2-[2-(3-fluorophenyl)-[1,2,4]triazolo[3,2-b][1,3]thiazol-6-yl]ethyl}-3,5-dimethylbenzamide

IUPAC name

N-{2-[2-(3-fluorophenyl)-[124]triazolo[32-b][13]thiazol-6-yl]ethyl}-35-dimethylbenzamide

SMILES

Cc1cc(C(NCCc2csc3nc(-c4cc(F)ccc4)nn23)=O)cc(C)c1

InChI

InChI=1S/C21H19FN4OS/c1-13-8-14(2)10-16(9-13)20(27)23-7-6-18-12-28-21-24-19(25-26(18)21)15-4-3-5-17(22)11-15/h3-5,8-12H,6-7H2,1-2H3,(H,23,27)

InChI Key

FNRIRVVBQBSMPB-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD08010115

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

394.47

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

4.494

Distribution Coefficient, logD

4.494

Water Solubility, LogSw

-4.33

Polar Surface Area

45.698

Acid Dissociation Constant (pKa)

12.26

Base Dissociation Constant (pKb)

2.78

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

19.00

G574-0272 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Histone Deacetylases (HDAC) Targeted Library (9760 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Nervous system
  • Hemic and lymphatic
  • Endocrine
  • Immune system
Targets:
  • Kinases
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with G574-0272 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G574-0272?
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What is the minimum amount of G574-0272 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G574-0272
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G574-0272
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G574-0272 available by request