G843-0477 Screening compound: ethyl 4-{1-[(2-chloro-6-fluorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate

G843-0477 Screening compound: ethyl 4-{1-[(2-chloro-6-fluorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate
G843-0477 Screening compound: ethyl 4-{1-[(2-chloro-6-fluorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate alternative view

Chemical Structure Depiction of ChemDiv screening compound G843-0477
ethyl 4-{1-[(2-chloro-6-fluorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G843-0477

Molecular Formula

C22H18ClFN2O4 (C22 H18 ClFN2 O4)

Compound Name

ethyl 4-{1-[(2-chloro-6-fluorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}benzoate

IUPAC name

ethyl 4-{1-[(2-chloro-6-fluorophenyl)methyl]-6-oxo-16-dihydropyridine-3-amido}benzoate

SMILES

CCOC(c(cc1)ccc1NC(C(C=C1)=CN(Cc(c(F)ccc2)c2Cl)C1=O)=O)=O

InChI

InChI=1S/C22H18ClFN2O4/c1-2-30-22(29)14-6-9-16(10-7-14)25-21(28)15-8-11-20(27)26(12-15)13-17-18(23)4-3-5-19(17)24/h3-12H,2,13H2,1H3,(H,25,28)

InChI Key

KYCAHNIDHYUKRE-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD09247599

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

428.85

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.919

Distribution Coefficient, logD

3.692

Water Solubility, LogSw

-4.46

Polar Surface Area

60.594

Acid Dissociation Constant (pKa)

7.56

Base Dissociation Constant (pKb)

-1.18

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

13.60

G843-0477 in Drug Discovery

Included in Screening Libraries

C-Met Library (15277 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
Targets:
  • Kinases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with G843-0477 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G843-0477?
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What is the minimum amount of G843-0477 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G843-0477
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G843-0477
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G843-0477 available by request