H027-4299 Screening compound: (1r3r)-3-methoxy-2244-tetramethylcyclobutyl (2S)-2-{[(R)-{[(2R3R4R5R)-5-(24-dioxo-1234-tetrahydropyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate

H027-4299 Screening compound: (1r3r)-3-methoxy-2244-tetramethylcyclobutyl (2S)-2-{[(R)-{[(2R3R4R5R)-5-(24-dioxo-1234-tetrahydropyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
H027-4299 Screening compound: (1r3r)-3-methoxy-2244-tetramethylcyclobutyl (2S)-2-{[(R)-{[(2R3R4R5R)-5-(24-dioxo-1234-tetrahydropyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate alternative view

Chemical Structure Depiction of ChemDiv screening compound H027-4299
(1r3r)-3-methoxy-2244-tetramethylcyclobutyl (2S)-2-{[(R)-{[(2R3R4R5R)-5-(24-dioxo-1234-tetrahydropyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

H027-4299

Molecular Formula

C28H39FN3O10P (C28 H39 FN3 O10 P)

Compound Name

(1r3r)-3-methoxy-2244-tetramethylcyclobutyl (2S)-2-{[(R)-{[(2R3R4R5R)-5-(24-dioxo-1234-tetrahydropyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate

IUPAC name

(1r3r)-3-methoxy-2244-tetramethylcyclobutyl (2S)-2-{[(R)-{[(2R3R4R5R)-5-(24-dioxo-1234-tetrahydropyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate

SMILES

C[C@@H](C(O[C@H](C1(C)C)C(C)(C)[C@@H]1OC)=O)N[P@@](OC[C@H]([C@H]([C@@]1(C)F)O)O[C@H]1N(C=CC(N1)=O)C1=O)(Oc1ccccc1)=O

InChI

InChI=1S/C28H39FN3O10P/c1-16(21(35)41-23-26(2,3)22(38-7)27(23,4)5)31-43(37,42-17-11-9-8-10-12-17)39-15-18-20(34)28(6,29)24(40-18)32-14-13-19(33)30-25(32)36/h8-14,16,18,20,22-24,34H,15H2,1-7H3,(H,31,37)(H,30,33,36)/t16-,18+,20+,22?,23?,24-,28+,43+/m0/s1

InChI Key

MKPLQLXDYYAAJJ-RTIGPEOSSA-N

MDL Number (MFCD)

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

627.6

Hydrogen Bond Acceptors Count

15.00

Hydrogen Bond Donors Count

3.00

Rotatable Bond Count

12.00

Number of Nitrogen and Oxygen Atoms

13

Partition Coefficient, logP

2.177

Distribution Coefficient, logD

2.176

Water Solubility, LogSw

-2.71

Polar Surface Area

133.017

Acid Dissociation Constant (pKa)

10.21

Base Dissociation Constant (pKb)

2.71

Number of Chiral Centers

6.00

Percent sp3 carbon bonding

60.71

References: we are preparing a list of scientific research reports with H027-4299 chemical compound. It will be published here after verification.

Frequently Asked Questions

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What is the minimum amount of H027-4299 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for H027-4299
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for H027-4299
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of H027-4299 available by request