J026-4237 Screening compound: methyl 2-{2-[1,7-dimethyl-2,4-dioxo-5-(piperidine-1-carbonyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-3-yl]acetamido}benzoate

J026-4237 Screening compound: methyl 2-{2-[1,7-dimethyl-2,4-dioxo-5-(piperidine-1-carbonyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-3-yl]acetamido}benzoate
J026-4237 Screening compound: methyl 2-{2-[1,7-dimethyl-2,4-dioxo-5-(piperidine-1-carbonyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-3-yl]acetamido}benzoate alternative view

Chemical Structure Depiction of ChemDiv screening compound J026-4237
methyl 2-{2-[1,7-dimethyl-2,4-dioxo-5-(piperidine-1-carbonyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-3-yl]acetamido}benzoate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

J026-4237

Molecular Formula

C25H27N5O6 (C25 H27 N5 O6)

Compound Name

methyl 2-{2-[1,7-dimethyl-2,4-dioxo-5-(piperidine-1-carbonyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-3-yl]acetamido}benzoate

IUPAC name

methyl 2-{2-[17-dimethyl-24-dioxo-5-(piperidine-1-carbonyl)-1H2H3H4H-pyrido[23-d]pyrimidin-3-yl]acetamido}benzoate

SMILES

Cc(cc1C(N2CCCCC2)=O)nc(N(C)C(N2CC(Nc(cccc3)c3C(OC)=O)=O)=O)c1C2=O

InChI

InChI=1S/C25H27N5O6/c1-15-13-17(22(32)29-11-7-4-8-12-29)20-21(26-15)28(2)25(35)30(23(20)33)14-19(31)27-18-10-6-5-9-16(18)24(34)36-3/h5-6,9-10,13H,4,7-8,11-12,14H2,1-3H3,(H,27,31)

InChI Key

BNRJLFNEIBQMDP-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD11854877

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

493.52

Hydrogen Bond Acceptors Count

12.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

11

Partition Coefficient, logP

2.218

Distribution Coefficient, logD

2.212

Water Solubility, LogSw

-3.11

Polar Surface Area

101.283

Acid Dissociation Constant (pKa)

9.25

Base Dissociation Constant (pKb)

2.86

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

36.00

J026-4237 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Hsp90-Targeted Library (11355 compounds)

Protein Arginine Methyltransferases Library (27925 compounds)

Protein-Protein Interaction Library (218420 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • Epigenetic
  • PPI modulators

References: we are preparing a list of scientific research reports with J026-4237 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound J026-4237?
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What is the minimum amount of J026-4237 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for J026-4237
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for J026-4237
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of J026-4237 available by request