K216-0459 Screening compound: 6-(4-fluorophenyl)-2,3-bis(4-methylphenyl)imidazo[1,2-b][1,2,4]triazine

K216-0459 Screening compound: 6-(4-fluorophenyl)-2,3-bis(4-methylphenyl)imidazo[1,2-b][1,2,4]triazine
K216-0459 Screening compound: 6-(4-fluorophenyl)-2,3-bis(4-methylphenyl)imidazo[1,2-b][1,2,4]triazine alternative view

Chemical Structure Depiction of ChemDiv screening compound K216-0459
6-(4-fluorophenyl)-2,3-bis(4-methylphenyl)imidazo[1,2-b][1,2,4]triazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K216-0459

Molecular Formula

C25H19FN4 (C25 H19 FN4)

Compound Name

6-(4-fluorophenyl)-2,3-bis(4-methylphenyl)imidazo[1,2-b][1,2,4]triazine

IUPAC name

6-(4-fluorophenyl)-23-bis(4-methylphenyl)imidazo[12-b][124]triazine

SMILES

Cc(cc1)ccc1-c1nc2nc(-c(cc3)ccc3F)cn2nc1-c1ccc(C)cc1

InChI

InChI=1S/C25H19FN4/c1-16-3-7-19(8-4-16)23-24(20-9-5-17(2)6-10-20)29-30-15-22(27-25(30)28-23)18-11-13-21(26)14-12-18/h3-15H,1-2H3

InChI Key

JZFCIYBRIGPQCH-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD02935055

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

394.45

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

6.012

Distribution Coefficient, logD

6.011

Water Solubility, LogSw

-5.72

Polar Surface Area

30.704

Acid Dissociation Constant (pKa)

28.37

Base Dissociation Constant (pKb)

3.80

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

8.00

K216-0459 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

KRAS-Targeted Library (16000 compounds)

Protein-Protein Interaction Library (218420 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with K216-0459 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K216-0459?
Check Price and Availability of K216-0459, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of K216-0459 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K216-0459
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K216-0459
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K216-0459 available by request